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Hapten-Specific Immune Response Producing Glomerular Injury
http://hdl.handle.net/10191/33457
http://hdl.handle.net/10191/33457ab0bd5fe-f2d7-4624-bf31-d9f90e3ffeed
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
39(Suppl.)_31-33.pdf (366.2 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-09-28 | |||||
| タイトル | ||||||
| タイトル | Hapten-Specific Immune Response Producing Glomerular Injury | |||||
| タイトル | ||||||
| タイトル | Hapten-Specific Immune Response Producing Glomerular Injury | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Oite, Takashi
× Oite, Takashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A new experimental model using a cationic hapten-carrier system was established. Attachment of the hapten, trinitrophenol (TNP) to cationic carrier proteins (human IgG; hIgG, bovine serum albumin; BSA) enables their inplantation into the glomerular capillary wall. The TNP bound to the glomerular capillary wall can act as a target molecule not only for circulating antibody, leading to in situ immune complex formation, but also for cell mediated immune response. Epicutaneous sensitization of the TNP without carrier protein induced a TNP-specific cell-mediated immunity. When the left kidneys of these sensitized rats were perfused with cationized TNP-BSA, proliferative glomerulonephritis with proteinuria could be induced without deposition of any autologous immunoglobulins or complement. This line of approach enables us to analyse several factors involved in the glomerular injury at the cellular and molecular levels. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 39(Supplement), p. 31-33, 発行日 1991-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
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| 値 | publisher | |||||
