@article{oai:niigata-u.repo.nii.ac.jp:00006575,
 author = {Oite, Takashi},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Mar},
 note = {A new experimental model using a cationic hapten-carrier system was established. Attachment of the hapten, trinitrophenol (TNP) to cationic carrier proteins (human IgG; hIgG, bovine serum albumin; BSA) enables their inplantation into the glomerular capillary wall. The TNP bound to the glomerular capillary wall can act as a target molecule not only for circulating antibody, leading to in situ immune complex formation, but also for cell mediated immune response. Epicutaneous sensitization of the TNP without carrier protein induced a TNP-specific cell-mediated immunity. When the left kidneys of these sensitized rats were perfused with cationized TNP-BSA, proliferative glomerulonephritis with proteinuria could be induced without deposition of any autologous immunoglobulins or complement. This line of approach enables us to analyse several factors involved in the glomerular injury at the cellular and molecular levels.},
 pages = {31--33},
 title = {Hapten-Specific Immune Response Producing Glomerular Injury},
 volume = {39(Supplement)},
 year = {1991}
}