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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.40 No.2

Diurnal Variation of Fibrinolytic Response to Venous Occlusion

http://hdl.handle.net/10191/33380
http://hdl.handle.net/10191/33380
4eb22de3-76cc-4092-a691-8d339343661c
名前 / ファイル ライセンス アクション
40(2)_73-77.pdf 40(2)_73-77.pdf (579.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-18
タイトル
タイトル Diurnal Variation of Fibrinolytic Response to Venous Occlusion
タイトル
タイトル Diurnal Variation of Fibrinolytic Response to Venous Occlusion
言語 en
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Niwano, Hiroe

× Niwano, Hiroe

WEKO 53499

Niwano, Hiroe

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Takahashi, Hoyu

× Takahashi, Hoyu

WEKO 53500

Takahashi, Hoyu

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Hanano, Masaharu

× Hanano, Masaharu

WEKO 53501

Hanano, Masaharu

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Tatewaki, Wataru

× Tatewaki, Wataru

WEKO 53502

Tatewaki, Wataru

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Wada, Ken

× Wada, Ken

WEKO 53503

Wada, Ken

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Seki, Yoshinobu

× Seki, Yoshinobu

WEKO 53504

Seki, Yoshinobu

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Shibata, Akira

× Shibata, Akira

WEKO 53505

Shibata, Akira

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抄録
内容記述タイプ Abstract
内容記述 The fibrinolytic system has a circadian variationwhich has been attributed to changes in plasma concentrations of the tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1). PAI-1 has two forms, an active form and latent form; the active form PAI-1 rapidly inactivates t-PA by forming a t-PA/PAI-1 complex. In order to investigate the diurnal variation of the fibrinolytic response of endothelial cells, plasma levels of t-PA antigen, plasminogen activator (PA) activity, PAI-1 antigen, plasminogen activator inhibitor (PAI) activity, and t-PA/PAI-1 complex were measured before and after venous occlusion at 8 A.M. and 4 P.M. in eight healthy subjects. The venous occlusion was performed on the arm at the mean pressure and plasma samples were obtained from the antecubital vein. The basal levels of PAI activity, PAI-1 antigen and t-PA/PAI-1 complex were relatively high in the morning, and the basal PA activity was relatively low in the morning. After venous occlusion, t-PA antigen and t-PA/PAI-1 complex were more increased in the morning than in the evening. However, the levels of PA activity, PAI activity, and PAI-1 antigen similarly increased after venous occlusion both in the morning and in the evening. These findings indicate that, although the basal fibrinolytic activity is low due to the elevation of PAI in the morning, the fibrinolytic response to venous occlusion is similar to that observed in the evening.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 40, 号 2, p. 73-77, 発行日 1992-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
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Niwano, Hiroe, Takahashi, Hoyu, Hanano, Masaharu, Tatewaki, Wataru, Wada, Ken, Seki, Yoshinobu, Shibata, Akira, 1992, Diurnal Variation of Fibrinolytic Response to Venous Occlusion: Niigata University School of Medicine, 73–77 p.

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