@article{oai:niigata-u.repo.nii.ac.jp:00006563,
 author = {Niwano, Hiroe and Takahashi, Hoyu and Hanano, Masaharu and Tatewaki, Wataru and Wada, Ken and Seki, Yoshinobu and Shibata, Akira},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {The fibrinolytic system has a circadian variationwhich has been attributed to changes in plasma concentrations of the tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1). PAI-1 has two forms, an active form and latent form; the active form PAI-1 rapidly inactivates t-PA by forming a t-PA/PAI-1 complex. In order to investigate the diurnal variation of the fibrinolytic response of endothelial cells, plasma levels of t-PA antigen, plasminogen activator (PA) activity, PAI-1 antigen, plasminogen activator inhibitor (PAI) activity, and t-PA/PAI-1 complex were measured before and after venous occlusion at 8 A.M. and 4 P.M. in eight healthy subjects. The venous occlusion was performed on the arm at the mean pressure and plasma samples were obtained from the antecubital vein. The basal levels of PAI activity, PAI-1 antigen and t-PA/PAI-1 complex were relatively high in the morning, and the basal PA activity was relatively low in the morning. After venous occlusion, t-PA antigen and t-PA/PAI-1 complex were more increased in the morning than in the evening. However, the levels of PA activity, PAI activity, and PAI-1 antigen similarly increased after venous occlusion both in the morning and in the evening. These findings indicate that, although the basal fibrinolytic activity is low due to the elevation of PAI in the morning, the fibrinolytic response to venous occlusion is similar to that observed in the evening.},
 pages = {73--77},
 title = {Diurnal Variation of Fibrinolytic Response to Venous Occlusion},
 volume = {40},
 year = {1992}
}