{"_buckets": {"deposit": "838b8f94-b86c-4d84-ba7b-d3b6991ac97c"}, "_deposit": {"id": "6561", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6561"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006561", "sets": ["456", "636"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "67", "bibliographicPageStart": "59", "bibliographicVolumeNumber": "40", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "To clarify useful indicators during treatment with interferon-α (IFN-α) against chronic hepatitis C, 25 patients were surveilled. Several viral markers for the evaluation of the effects of IFN therapy were examined. The antibody to C100 (anti-C100), antibody to the protein encoded in the core region of HCV (anti-core), and hepatitis C virus RNA (HCV-RNA) by polymerase chain reaction (PCR) were assayed before and after IFN treatment in each patient. In 6 out of 25 patients, alanine aminotransferase (ALT) levels decreased to normal values within 6 months after IFN therapy and remained within the normal range thereafter. In 8 patients, ALT levels showed transient normal levels within one month after the therapy, but in the other 11 patients, ALT levels did not change during the course of IFN therapy. In 6 patients with good responses and 8 patients with transient responses, histological findings in the liver biopsy specimens before treatment were more moderately changed than those in patients with no response to IFN. Titers of anti-C100 before treatment in patients with good responses to IFN were higher than those in patients with no response. Changes in the titers of anti-C100 and anti-core and changes of HCV-RNA in each patient correlated well with the changes in serum aminotransferase levels. Therefore, HCV antibody titers and HCV-RNA are considered to be useful indicators in predicting the prognoses of patients who receive IFN therapy.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kobayashi, Tadashi"}], "nameIdentifiers": [{"nameIdentifier": "53493", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "40(2)_59-67.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "40(2)_59-67.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6561/files/40(2)_59-67.pdf"}, "version_id": "b80553e5-44dd-4383-9166-9ee5cfa19136"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Titers of Antibodies Associated with Hepatitis C Virus during and after Interferon Therapy : Evaluation of anti-C100 and anti-core antibodies", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Titers of Antibodies Associated with Hepatitis C Virus during and after Interferon Therapy : Evaluation of anti-C100 and anti-core antibodies"}, {"subitem_title": "Titers of Antibodies Associated with Hepatitis C Virus during and after Interferon Therapy : Evaluation of anti-C100 and anti-core antibodies", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "636"], "permalink_uri": "http://hdl.handle.net/10191/33378", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-09-18"}, "publish_date": "2015-09-18", "publish_status": "0", "recid": "6561", "relation": {}, "relation_version_is_last": true, "title": ["Titers of Antibodies Associated with Hepatitis C Virus during and after Interferon Therapy : Evaluation of anti-C100 and anti-core antibodies"], "weko_shared_id": null}