{"created":"2021-03-01T06:10:28.408174+00:00","id":6561,"links":{},"metadata":{"_buckets":{"deposit":"838b8f94-b86c-4d84-ba7b-d3b6991ac97c"},"_deposit":{"id":"6561","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6561"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006561","sets":["453:456","471:537:568:636"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"67","bibliographicPageStart":"59","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To clarify useful indicators during treatment with interferon-α (IFN-α) against chronic hepatitis C, 25 patients were surveilled. Several viral markers for the evaluation of the effects of IFN therapy were examined. The antibody to C100 (anti-C100), antibody to the protein encoded in the core region of HCV (anti-core), and hepatitis C virus RNA (HCV-RNA) by polymerase chain reaction (PCR) were assayed before and after IFN treatment in each patient. In 6 out of 25 patients, alanine aminotransferase (ALT) levels decreased to normal values within 6 months after IFN therapy and remained within the normal range thereafter. In 8 patients, ALT levels showed transient normal levels within one month after the therapy, but in the other 11 patients, ALT levels did not change during the course of IFN therapy. In 6 patients with good responses and 8 patients with transient responses, histological findings in the liver biopsy specimens before treatment were more moderately changed than those in patients with no response to IFN. Titers of anti-C100 before treatment in patients with good responses to IFN were higher than those in patients with no response. Changes in the titers of anti-C100 and anti-core and changes of HCV-RNA in each patient correlated well with the changes in serum aminotransferase levels. Therefore, HCV antibody titers and HCV-RNA are considered to be useful indicators in predicting the prognoses of patients who receive IFN therapy.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kobayashi, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"53493","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"40(2)_59-67.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"40(2)_59-67.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6561/files/40(2)_59-67.pdf"},"version_id":"b80553e5-44dd-4383-9166-9ee5cfa19136"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Titers of Antibodies Associated with Hepatitis C Virus during and after Interferon Therapy : Evaluation of anti-C100 and anti-core antibodies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Titers of Antibodies Associated with Hepatitis C Virus during and after Interferon Therapy : Evaluation of anti-C100 and anti-core antibodies"},{"subitem_title":"Titers of Antibodies Associated with Hepatitis C Virus during and after Interferon Therapy : Evaluation of anti-C100 and anti-core antibodies","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","636"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-18"},"publish_date":"2015-09-18","publish_status":"0","recid":"6561","relation_version_is_last":true,"title":["Titers of Antibodies Associated with Hepatitis C Virus during and after Interferon Therapy : Evaluation of anti-C100 and anti-core antibodies"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:51.991975+00:00"}