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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.40 No.4

Immunological Monitoring of the Peripheral Blood Mononuclear Cell by Two-Color Flow Cytometry after Local Administration of OK-432 in a Patient with Gastric Cancer Displaying Multiple Liver Metastasis

http://hdl.handle.net/10191/33392
http://hdl.handle.net/10191/33392
43c7a7a2-c4ba-4ab8-9c42-c721808c66c9
名前 / ファイル ライセンス アクション
40(4)_151-156.pdf 40(4)_151-156.pdf (1.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-18
タイトル
タイトル Immunological Monitoring of the Peripheral Blood Mononuclear Cell by Two-Color Flow Cytometry after Local Administration of OK-432 in a Patient with Gastric Cancer Displaying Multiple Liver Metastasis
タイトル
言語 en
タイトル Immunological Monitoring of the Peripheral Blood Mononuclear Cell by Two-Color Flow Cytometry after Local Administration of OK-432 in a Patient with Gastric Cancer Displaying Multiple Liver Metastasis
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Sato, Yoshinobu

× Sato, Yoshinobu

WEKO 53439

Sato, Yoshinobu

Search repository
Fukuda, Minoru

× Fukuda, Minoru

WEKO 53440

Fukuda, Minoru

Search repository
抄録
内容記述タイプ Abstract
内容記述 A trial administration of OK-432 by transarterial embolization (TAE) and intra-operative local injection (OLI) was performed to treat the liver metastasis of gastric cancer. The liver metastases decreased in size as assessed by abdominal CT scan. The peripheral level of DR^+ CD3^- monocytes (antigen-presenting cell) were increased on the day following OK-432 administration, and the increase in CD4^+ T lymphocytes (helper T cell) was prominent from 3 to 5 days afterward. Furthermore, the CD8^+ T lymphocyte (cytotxic T cell) level increased from 5 to 7 days after OK-432 treatment. The increase in the number of these lymphocytes after OLI with OK-432 was more prominent than that after TAE with OK--432. The concentration of DR^+CD4^+ T lymphocytes changed little, however, DR^+CD8^+ T lymphocytes increasing remarkably after TAE and OLI. NK activities decreased significantly on the day following TAE and abdominal operation, but increased afterward to at least pretreatment levels. On two-color flow cytometry using LEU 7 and LEU 11, which recognize NK surface antigens, each subpopulation of NK cells showed similar changes. However, LEU 11-positive cells comprised the majority of the NK cells. The kinetics of the NK subpopulation did not always correspond to that of NK activity, which may be due to the participation of neutrophils induced\nby the liver biopsy. These results suggest that the local administration of OK-432 by TAE and OLI activates cell mediated immunity by stimulating antigen-presenting cells and helper and cytotoxic T cells, and may therefore be used to treat liver metastasis.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 40, 号 4, p. 151-156, 発行日 1992-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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