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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.41 No.1

Glucagon-like Immunoreactivity in Chronic Renal Failure

http://hdl.handle.net/10191/33313
http://hdl.handle.net/10191/33313
976d9315-7c24-40ef-90c7-cc274c78fee2
名前 / ファイル ライセンス アクション
41(1)_17-24.pdf 41(1)_17-24.pdf (822.7 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-11
タイトル
タイトル Glucagon-like Immunoreactivity in Chronic Renal Failure
タイトル
言語 en
タイトル Glucagon-like Immunoreactivity in Chronic Renal Failure
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Ogawa, Atsushi

× Ogawa, Atsushi

WEKO 53383

Ogawa, Atsushi

Search repository
Suda, Katsuyuki

× Suda, Katsuyuki

WEKO 53384

Suda, Katsuyuki

Search repository
Yamatani, Keiichi

× Yamatani, Keiichi

WEKO 53385

Yamatani, Keiichi

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Igarashi, Masahiko

× Igarashi, Masahiko

WEKO 53386

Igarashi, Masahiko

Search repository
Daimon, Makoto

× Daimon, Makoto

WEKO 53387

Daimon, Makoto

Search repository
Tominaga, Makoto

× Tominaga, Makoto

WEKO 53388

Tominaga, Makoto

Search repository
Sasaki, Hideo

× Sasaki, Hideo

WEKO 53389

Sasaki, Hideo

Search repository
抄録
内容記述タイプ Abstract
内容記述 The modulation of glucagon-related peptides, plasma glucagon-like immunoreactivity (GLI) and plasma immunoreactive glucagon (IRG) were studied in 44 patients with chronic renal failure (CRF). The plasma levels of GLI and IRG during fasting were higher in the CRF patients than in the healthy control subjects and correlated well with renal dysfunction. Both plasma GLI and IRG levels increased after arginine infusion test. Following oral glucose ingestion, the response of plasma GLI levels was much greater in CRF than in the controls, but the plasma IRG levels in CRF were not decreased despite significant reduction in the controls. On gelfiltration of the plasma in CRF during fasting, both GLI and IRG were eluted at the position of 8-9 Kd, and the ratio of GLI to IRG in this fraction was 11.2. The authentic glucagon (3.5 Kd) appeared only in samples following arginine infusion. The 8-9 Kd GLI and IRG increased after oral ingestion of glucose, but not after arginine infusion. By electrofocusing column chromatography of the pooled 8-9 Kd fraction, GLI showed 3 peaks at pI 4.42, 5.12 and 5.94, and IRG showed a peak at pI 5, 12. These pIs were compatible to the pIs of peak I GLI obtained from canine intestinal extracts. Therefore, it is suggested that this large molecule GLI, especially prevalent in CRF patients, originates from the intestinal tract.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 41, 号 1, p. 17-24, 発行日 1993-03
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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