@article{oai:niigata-u.repo.nii.ac.jp:00006535,
 author = {Ogawa, Atsushi and Suda, Katsuyuki and Yamatani, Keiichi and Igarashi, Masahiko and Daimon, Makoto and Tominaga, Makoto and Sasaki, Hideo},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Mar},
 note = {The modulation of glucagon-related peptides, plasma glucagon-like immunoreactivity (GLI) and plasma immunoreactive glucagon (IRG) were studied in 44 patients with chronic renal failure (CRF). The plasma levels of GLI and IRG during fasting were higher in the CRF patients than in the healthy control subjects and correlated well with renal dysfunction. Both plasma GLI and IRG levels increased after arginine infusion test. Following oral glucose ingestion, the response of plasma GLI levels was much greater in CRF than in the controls, but the plasma IRG levels in CRF were not decreased despite significant reduction in the controls. On gelfiltration of the plasma in CRF during fasting, both GLI and IRG were eluted at the position of 8-9 Kd, and the ratio of GLI to IRG in this fraction was 11.2. The authentic glucagon (3.5 Kd) appeared only in samples following arginine infusion. The 8-9 Kd GLI and IRG increased after oral ingestion of glucose, but not after arginine infusion. By electrofocusing column chromatography of the pooled 8-9 Kd fraction, GLI showed 3 peaks at pI 4.42, 5.12 and 5.94, and IRG showed a peak at pI 5, 12. These pIs were compatible to the pIs of peak I GLI obtained from canine intestinal extracts. Therefore, it is suggested that this large molecule GLI, especially prevalent in CRF patients, originates from the intestinal tract.},
 pages = {17--24},
 title = {Glucagon-like Immunoreactivity in Chronic Renal Failure},
 volume = {41},
 year = {1993}
}