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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.42 No.2

Effects of Caffeine on the Pharmacokinetics of Paracetamol

http://hdl.handle.net/10191/33240
http://hdl.handle.net/10191/33240
787c84e5-cfb4-49d8-9734-53dd7cb60d45
名前 / ファイル ライセンス アクション
42(2)_51-55.pdf 42(2)_51-55.pdf (481.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-04
タイトル
タイトル Effects of Caffeine on the Pharmacokinetics of Paracetamol
タイトル
言語 en
タイトル Effects of Caffeine on the Pharmacokinetics of Paracetamol
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Wojcicki, Jerzy

× Wojcicki, Jerzy

WEKO 53237

Wojcicki, Jerzy

Search repository
Rainska-Giezek, Tamara

× Rainska-Giezek, Tamara

WEKO 53238

Rainska-Giezek, Tamara

Search repository
Gawronska-Szklarz, Barbara

× Gawronska-Szklarz, Barbara

WEKO 53239

Gawronska-Szklarz, Barbara

Search repository
Dutkiewicz-Serdynska, Grazyna

× Dutkiewicz-Serdynska, Grazyna

WEKO 53240

Dutkiewicz-Serdynska, Grazyna

Search repository
抄録
内容記述タイプ Abstract
内容記述 This study was undertaken to determine the effect of caffeine on paracetamol pharmacokinetics in normal subjects. Each person was examined two times (two phases) at one week intervals after the administration of two tablets (0.5 g of paracetamol +0.05 g of caffeine in one tablet) of Finimal (Roche-Nicholas B.V., Bladel, Netherlands) or two tablets (0.5 g of paracetamol in one tablet) of Paracetamol (Roche-Nicholas B. V., Bladel). The study was performed on two randomly assigned subgroups (cross-over). The blood was sampled before (0), and 0.25-0.5-1.0-1.25-1.5-2.0-4.0-6.0-8.0 h after drug administration. Plasma paracetamol was determined by an improved gas chromatographic method, as described by Thoma et al. The course of the changes in the drug concentrations in plasma was described with a one-compartment open model for extravascular administration. A comparison of paracetamol concentrations in the blood plasma after application of both paracetamol alone and paracetamol in combination with caffeine (Finimal) showed slightly depressed drug levels after the administration of Finimal. Significantly lower levels were observed after 0.5, 1.0 and 1.25 h. A comparison of pharmacokinetic parameters also indicated mild differences between Finimal and paracetamol alone. In subjects receiving Finimal, a decrease in C_<max>, k_a, k_<e1>, AUC and an increase in V_D, t_<max>, t_<0.5> and Cl_T, was observed. The obtained results may be summarized as follows: 1) There is a pharmacokinetic interaction between caffeine and paracetamol applied as a single therapeutic dose; 2) Such an interaction may attenuate liver toxicity.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 42, 号 2, p. 51-55, 発行日 1994-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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