@article{oai:niigata-u.repo.nii.ac.jp:00006501,
 author = {Wojcicki, Jerzy and Rainska-Giezek, Tamara and Gawronska-Szklarz, Barbara and Dutkiewicz-Serdynska, Grazyna},
 issue = {2},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Jun},
 note = {This study was undertaken to determine the effect of caffeine on paracetamol pharmacokinetics in normal subjects. Each person was examined two times (two phases) at one week intervals after the administration of two tablets (0.5 g of paracetamol +0.05 g of caffeine in one tablet) of Finimal (Roche-Nicholas B.V., Bladel, Netherlands) or two tablets (0.5 g of paracetamol in one tablet) of Paracetamol (Roche-Nicholas B. V., Bladel). The study was performed on two randomly assigned subgroups (cross-over). The blood was sampled before (0), and 0.25-0.5-1.0-1.25-1.5-2.0-4.0-6.0-8.0 h after drug administration. Plasma paracetamol was determined by an improved gas chromatographic method, as described by Thoma et al. The course of the changes in the drug concentrations in plasma was described with a one-compartment open model for extravascular administration. A comparison of paracetamol concentrations in the blood plasma after application of both paracetamol alone and paracetamol in combination with caffeine (Finimal) showed slightly depressed drug levels after the administration of Finimal. Significantly lower levels were observed after 0.5, 1.0 and 1.25 h. A comparison of pharmacokinetic parameters also indicated mild differences between Finimal and paracetamol alone. In subjects receiving Finimal, a decrease in C_<max>, k_a, k_<e1>, AUC and an increase in V_D, t_<max>, t_<0.5> and Cl_T, was observed. The obtained results may be summarized as follows: 1) There is a pharmacokinetic interaction between caffeine and paracetamol applied as a single therapeutic dose; 2) Such an interaction may attenuate liver toxicity.},
 pages = {51--55},
 title = {Effects of Caffeine on the Pharmacokinetics of Paracetamol},
 volume = {42},
 year = {1994}
}