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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.42 No.4

Acidosis rather than Ketosis Reduces Insulin Action during Metabolic Ketoacidosis : An Investigation by Glucose Clamp Study in the Rat

http://hdl.handle.net/10191/33254
http://hdl.handle.net/10191/33254
8e306ede-1d32-4cbc-81d9-e2ffc4507297
名前 / ファイル ライセンス アクション
42(4)_151-158.pdf 42(4)_151-158.pdf (764.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-09-04
タイトル
タイトル Acidosis rather than Ketosis Reduces Insulin Action during Metabolic Ketoacidosis : An Investigation by Glucose Clamp Study in the Rat
タイトル
言語 en
タイトル Acidosis rather than Ketosis Reduces Insulin Action during Metabolic Ketoacidosis : An Investigation by Glucose Clamp Study in the Rat
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Matsumoto, Mitsuo

× Matsumoto, Mitsuo

WEKO 53155

Matsumoto, Mitsuo

Search repository
Igarashi, Masahiko

× Igarashi, Masahiko

WEKO 53156

Igarashi, Masahiko

Search repository
Tominaga, Makoto

× Tominaga, Makoto

WEKO 53157

Tominaga, Makoto

Search repository
Daimon, Makoto

× Daimon, Makoto

WEKO 53158

Daimon, Makoto

Search repository
Fukase, Norio

× Fukase, Norio

WEKO 53159

Fukase, Norio

Search repository
Sugiyama, Kazuhiko

× Sugiyama, Kazuhiko

WEKO 53160

Sugiyama, Kazuhiko

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Ogawa, Atsushi

× Ogawa, Atsushi

WEKO 53161

Ogawa, Atsushi

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Yamatani, Keiichi

× Yamatani, Keiichi

WEKO 53162

Yamatani, Keiichi

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Sasaki, Hideo

× Sasaki, Hideo

WEKO 53163

Sasaki, Hideo

Search repository
抄録
内容記述タイプ Abstract
内容記述 To elucidate the occurrence of insulin resistance in metabolic ketoacidosis, we examined the hepatic glucose output (HGO) and glucose disappearance rate (Gd) by a euglycemic insulin clamp study on male Wistar rats under experimental metabolic ketosis and acidosis. Metabolic ketosis and acidosis were induced by the continuous intravenous infusion of either 3-hydroxybutyrate or ammonium chloride, respectively. Arterial blood gas analysis was performed by use of a blood gas analyzer. Insulin was infused at a rate of 3 mU/kg/min (low dose) or 20 mU/kg/min (high dose) during the glucose clamp course. Insulin sensitivity was evaluated by the mean of steady state glucose infusion rate (GIR) during the last 20 min. HGO and Gd were measured using 3- [_^3H] -glucose. Steady state GIR of acidotic rats was 2.65±0.25 mg/kg/min with low dose insulin and 7.22±0.42 mg/kg/min with high dose insulin. Thus, steady state GIR in both condition was significantly lower than those of the control rats. Steady state HGO of acidotic rats was not suppressed under low dose insulin infusion, while HGO of the normal control rats was completely suppressed. On the other hand, neither the GIR and HGO of the ketotic rats differed from those of the control. Our results suggest that metabolic acidosis rather than ketosis is responsible for insulin resistance in metabolic ketoacidosis.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 42, 号 4, p. 151-158, 発行日 1994-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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