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Specific Effects of 15-Deoxyspergualin on the Fat Metabolism in Partially Hepatectomized Rats
http://hdl.handle.net/10191/33222
http://hdl.handle.net/10191/33222c2d529ed-7806-4dd5-b764-2d3653b19d5a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
43(4)_229-232.pdf (441.7 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-31 | |||||
| タイトル | ||||||
| タイトル | Specific Effects of 15-Deoxyspergualin on the Fat Metabolism in Partially Hepatectomized Rats | |||||
| タイトル | ||||||
| タイトル | Specific Effects of 15-Deoxyspergualin on the Fat Metabolism in Partially Hepatectomized Rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lipid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cholesterolemia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | FK506 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | liver | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Date, Kazutoshi
× Date, Kazutoshi× Ohtake, Masahiro× Sakaguchi, Takeo× Aono, Takashi× Nihei, Kohei× Tsukada, Kazuhiro× Hatakeyama, Katsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Dynamic changes in fatty parameters in the blood and body were examined after 15-deoxyspergualin (DSG) or FK506 (FK) administration in 65% hepatectomized rats. The body composition of fatty parameters, the Lee-index and retroperitoneal white adipose tissue weight (RPWT) were estimated at 0, 1, 3, 5 and 7 days after hepatectomy. The serum total cholesterol concentration (Tch) and other valves including liver and kidney functions were also estimated. DSG 5 mg/kg increased Tch at 3 days after hepatectomy, then returned to the control level within an additional 2 days. On the other hand, RPWT decreased gradually following DSG injection, and a significanct decrease was observed 7 days after hepatectomy. No difference in Lee-index was seen among the groups. The food and water intake over 9 days and body weight gain after hepatectomy were similar among the three groups. DSG and FK increased blood urea nitrogen (BUN) levels compared with the control. Because the doses of agents utilized have been shown to stimulate liver regeneration, our results suggest that DSG at a dose stimulating liver regeneration produces a higher cholesterol level and promotes the catabolism of adipose tissue more slowly and continuously than FK. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 43, 号 4, p. 229-232, 発行日 1995-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
