WEKO3
アイテム
Archival Analysis of p53 Protein Overexpression and Genetic Mutation in Esophageal Squamous Cell Carcinoma
http://hdl.handle.net/10191/33161
http://hdl.handle.net/10191/3316165225e17-ad47-4780-8a31-6c877a4bd9ee
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
44(2)_63-69.pdf (1.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-27 | |||||
| タイトル | ||||||
| タイトル | Archival Analysis of p53 Protein Overexpression and Genetic Mutation in Esophageal Squamous Cell Carcinoma | |||||
| タイトル | ||||||
| タイトル | Archival Analysis of p53 Protein Overexpression and Genetic Mutation in Esophageal Squamous Cell Carcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p53 overexpression | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | p53 gene mutation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | esophageal carcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | clinicopathological factors | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Nakagawa, Satoru
× Nakagawa, Satoru× Watanabe, Hidenobu× Ajioka, Yoichi× Nishikura, Ken× Hitomi, Jiro× Hatakeyama, Katsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Alterations in p53 were analyzed by immunochemistry in 131 lesions from 108 patients and by polymerase chain reaction single-strand conformation polymorphism(PCR-SSCP) in 69 tumors from 69 patients with esophageal squamous cell carcinomas, to elucidate the correlation between protein overexpression and mutation, and between p53 alteration and clinicopathological factors. The p53 gene-product was overexpressed in 83 (63%) of the 131, and mutations were detected in 24 (35%) of the 69 tumors examined. The mutations were predominantly located at exons 5 (58%) and 7 (27%), and detected in 13 (31%) of 42 overexpressing tumors, in none of 4 sporadic tumors and in 8 (40%) of 20 negative tumors. The p53 alteration did not correlate with the clinicopathological factors, including pTNM categories, stage, depth of invasion, and size of intramucosal carcinomas. These results indicate that p53 protein overexpression and gene mutation may occur during an early stage of esophageal carcinogenesis and have no impact on clinicopathological factors. The higher frequency of p53 overexpression compared to mutation suggests that p53 accumulation can occur by other mechanisms besides p53 mutation. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 44, 号 2, p. 63-69, 発行日 1996-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
