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Inducing Activity of Respiratory Syncytial Virus on the Production of Macrophage Inflammatory Protein-2 in Murine Macrophages and Airway-lining Cells
http://hdl.handle.net/10191/33171
http://hdl.handle.net/10191/331710fc55172-e747-4383-9981-20e9fcbc3eeb
名前 / ファイル | ライセンス | アクション |
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44(3)_135-140.pdf (867.9 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-08-27 | |||||
タイトル | ||||||
タイトル | Inducing Activity of Respiratory Syncytial Virus on the Production of Macrophage Inflammatory Protein-2 in Murine Macrophages and Airway-lining Cells | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Inducing Activity of Respiratory Syncytial Virus on the Production of Macrophage Inflammatory Protein-2 in Murine Macrophages and Airway-lining Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | respiratory syncytial virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | macrophage inflammatory protein-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | interleukin-8 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | macrophages | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | airway-lining cells | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Ochiai, Hiroshi
× Ochiai, Hiroshi× Sakai, Shinya× Nakajima, Katsuhisa× Sakai, Takeshi× Terasawa, Katsutoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We investigated the macrophage inflammatory protein-2 (MIP-2)-producing activity of respiratory syncytial virus (RSV) in a murine macrophage cell line, RAW 264.7 cells, and airway-lining cells by the application of recently developed enzyme-linked immunosorbent assay (ELISA) system. The production of MIP-2 increased significantly in both cells by the infections of RSV in a dose-dependent manner. In addition to ELISA, MIP-2 production could be detected in RSV-infected airway-lining cells by immunocytochemical study. The heat-inactivated virus also enhanced MIP-2 production to comparable levels of the infections with the active virus. Time-related production showed a trend for a biphasic pattern, suggesting that this phenomenon might be due to the combined effects of the direct MIP-2-inducing activity of RSV and an indirect one via the initial production of other cytokines inducible for MIP-2 production. These data indicate that RSV, either in active or inactive form, has the potential to stimulate MIP-2 production in a cultured macrophage cell line and airway-lining cells. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 44, 号 3, p. 135-140, 発行日 1996-09 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |