{"created":"2021-03-01T06:10:19.943919+00:00","id":6426,"links":{},"metadata":{"_buckets":{"deposit":"8d5c96d0-fd27-4c98-a1b5-4b52caff3e31"},"_deposit":{"id":"6426","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6426"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006426","sets":["453:456","471:537:568:618"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"140","bibliographicPageStart":"135","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the macrophage inflammatory protein-2 (MIP-2)-producing activity of respiratory syncytial virus (RSV) in a murine macrophage cell line, RAW 264.7 cells, and airway-lining cells by the application of recently developed enzyme-linked immunosorbent assay (ELISA) system. The production of MIP-2 increased significantly in both cells by the infections of RSV in a dose-dependent manner. In addition to ELISA, MIP-2 production could be detected in RSV-infected airway-lining cells by immunocytochemical study. The heat-inactivated virus also enhanced MIP-2 production to comparable levels of the infections with the active virus. Time-related production showed a trend for a biphasic pattern, suggesting that this phenomenon might be due to the combined effects of the direct MIP-2-inducing activity of RSV and an indirect one via the initial production of other cytokines inducible for MIP-2 production. These data indicate that RSV, either in active or inactive form, has the potential to stimulate MIP-2 production in a cultured macrophage cell line and airway-lining cells.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ochiai, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"52857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Shinya"}],"nameIdentifiers":[{"nameIdentifier":"52858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Katsuhisa"}],"nameIdentifiers":[{"nameIdentifier":"52859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"52860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Terasawa, Katsutoshi"}],"nameIdentifiers":[{"nameIdentifier":"52861","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"44(3)_135-140.pdf","filesize":[{"value":"867.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"44(3)_135-140.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6426/files/44(3)_135-140.pdf"},"version_id":"614db38d-f49c-4eb3-ad02-809592c28f67"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"respiratory syncytial virus","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage inflammatory protein-2","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-8","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophages","subitem_subject_scheme":"Other"},{"subitem_subject":"airway-lining cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inducing Activity of Respiratory Syncytial Virus on the Production of Macrophage Inflammatory Protein-2 in Murine Macrophages and Airway-lining Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inducing Activity of Respiratory Syncytial Virus on the Production of Macrophage Inflammatory Protein-2 in Murine Macrophages and Airway-lining Cells"},{"subitem_title":"Inducing Activity of Respiratory Syncytial Virus on the Production of Macrophage Inflammatory Protein-2 in Murine Macrophages and Airway-lining Cells","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","618"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-27"},"publish_date":"2015-08-27","publish_status":"0","recid":"6426","relation_version_is_last":true,"title":["Inducing Activity of Respiratory Syncytial Virus on the Production of Macrophage Inflammatory Protein-2 in Murine Macrophages and Airway-lining Cells"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:43.627816+00:00"}