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Antitumor Effects of a Novel Sulfonamide, E7010, on Human Ovarian Cancer Cell Lines in Vitro and in Vivo
http://hdl.handle.net/10191/33181
http://hdl.handle.net/10191/33181e66e0091-7ce4-4c1a-9b98-2a833f3d50e8
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-08-27 | |||||
タイトル | ||||||
タイトル | Antitumor Effects of a Novel Sulfonamide, E7010, on Human Ovarian Cancer Cell Lines in Vitro and in Vivo | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Antitumor Effects of a Novel Sulfonamide, E7010, on Human Ovarian Cancer Cell Lines in Vitro and in Vivo | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sulfonamide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | E7010 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ovarian cancer | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Kikuchi, Akira
× Kikuchi, Akira |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We evaluated the antitumor effectiveness of a novel sulfonamide, N-[2-[(4-hydroxyphenyl) amino]-3-pyridinyl] -4-methoxybenzenesulfonamide (E7010), against 10 human ovarian cancer cell lines in vitro. The 50% inhibitory concentrations of E7010 for these cell lines ranged from 0.032 μg/ml to 0.48 μg/ml. Those of cisplatin (CDDP) ranged from 0.021 μg/ml to 1.0 μg/ml. No CDDP-resistant cell lines used in this study showed cross-resistance to E7010. In mice inoculated with Nakajima and KF cells, administration of E7010 in doses of 200-450 mg/kg every 5 days inhibited tumor growth by 11-79%. Moreover, the E7010-treated mice showed less body weight loss than the CDDP-treated mice at doses exerting equal antitumor effects. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 44, 号 4, p. 193-197, 発行日 1996-12 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |