WEKO3
アイテム
{"_buckets": {"deposit": "22ad5221-ed5a-49bd-bf62-c8995b967014"}, "_deposit": {"id": "6419", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6419"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006419", "sets": ["456", "617"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1996-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "197", "bibliographicPageStart": "193", "bibliographicVolumeNumber": "44", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We evaluated the antitumor effectiveness of a novel sulfonamide, N-[2-[(4-hydroxyphenyl) amino]-3-pyridinyl] -4-methoxybenzenesulfonamide (E7010), against 10 human ovarian cancer cell lines in vitro. The 50% inhibitory concentrations of E7010 for these cell lines ranged from 0.032 μg/ml to 0.48 μg/ml. Those of cisplatin (CDDP) ranged from 0.021 μg/ml to 1.0 μg/ml. No CDDP-resistant cell lines used in this study showed cross-resistance to E7010. In mice inoculated with Nakajima and KF cells, administration of E7010 in doses of 200-450 mg/kg every 5 days inhibited tumor growth by 11-79%. Moreover, the E7010-treated mice showed less body weight loss than the CDDP-treated mice at doses exerting equal antitumor effects.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Kikuchi, Akira"}], "nameIdentifiers": [{"nameIdentifier": "52824", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "44(4)_193-197.pdf", "filesize": [{"value": "587.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 587600.0, "url": {"label": "44(4)_193-197.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6419/files/44(4)_193-197.pdf"}, "version_id": "01d8af05-f901-49bf-aba4-9db110487ce0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "sulfonamide", "subitem_subject_scheme": "Other"}, {"subitem_subject": "E7010", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ovarian cancer", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Antitumor Effects of a Novel Sulfonamide, E7010, on Human Ovarian Cancer Cell Lines in Vitro and in Vivo", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Antitumor Effects of a Novel Sulfonamide, E7010, on Human Ovarian Cancer Cell Lines in Vitro and in Vivo"}, {"subitem_title": "Antitumor Effects of a Novel Sulfonamide, E7010, on Human Ovarian Cancer Cell Lines in Vitro and in Vivo", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "617"], "permalink_uri": "http://hdl.handle.net/10191/33181", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-08-27"}, "publish_date": "2015-08-27", "publish_status": "0", "recid": "6419", "relation": {}, "relation_version_is_last": true, "title": ["Antitumor Effects of a Novel Sulfonamide, E7010, on Human Ovarian Cancer Cell Lines in Vitro and in Vivo"], "weko_shared_id": null}
Antitumor Effects of a Novel Sulfonamide, E7010, on Human Ovarian Cancer Cell Lines in Vitro and in Vivo
http://hdl.handle.net/10191/33181
http://hdl.handle.net/10191/33181e66e0091-7ce4-4c1a-9b98-2a833f3d50e8
名前 / ファイル | ライセンス | アクション |
---|---|---|
44(4)_193-197.pdf (587.6 kB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2015-08-27 | |||||
タイトル | ||||||
タイトル | Antitumor Effects of a Novel Sulfonamide, E7010, on Human Ovarian Cancer Cell Lines in Vitro and in Vivo | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Antitumor Effects of a Novel Sulfonamide, E7010, on Human Ovarian Cancer Cell Lines in Vitro and in Vivo | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sulfonamide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | E7010 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ovarian cancer | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Kikuchi, Akira
× Kikuchi, Akira |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We evaluated the antitumor effectiveness of a novel sulfonamide, N-[2-[(4-hydroxyphenyl) amino]-3-pyridinyl] -4-methoxybenzenesulfonamide (E7010), against 10 human ovarian cancer cell lines in vitro. The 50% inhibitory concentrations of E7010 for these cell lines ranged from 0.032 μg/ml to 0.48 μg/ml. Those of cisplatin (CDDP) ranged from 0.021 μg/ml to 1.0 μg/ml. No CDDP-resistant cell lines used in this study showed cross-resistance to E7010. In mice inoculated with Nakajima and KF cells, administration of E7010 in doses of 200-450 mg/kg every 5 days inhibited tumor growth by 11-79%. Moreover, the E7010-treated mice showed less body weight loss than the CDDP-treated mice at doses exerting equal antitumor effects. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 44, 号 4, p. 193-197, 発行日 1996-12 |
|||||
出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |