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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.45 No.3

Effect of Intraluminal Administration of Insulin-like Growth Factor-I on Rats with Methotrexate-induced Enterocolitis

http://hdl.handle.net/10191/33129
http://hdl.handle.net/10191/33129
e53b602a-e068-4554-bc2d-a4eef3960364
名前 / ファイル ライセンス アクション
45(3)_115-119.pdf 45(3)_115-119.pdf (826.5 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-25
タイトル
タイトル Effect of Intraluminal Administration of Insulin-like Growth Factor-I on Rats with Methotrexate-induced Enterocolitis
タイトル
言語 en
タイトル Effect of Intraluminal Administration of Insulin-like Growth Factor-I on Rats with Methotrexate-induced Enterocolitis
言語
言語 eng
キーワード
主題Scheme Other
主題 insulin-like growth factor I
キーワード
主題Scheme Other
主題 IGF-I
キーワード
主題Scheme Other
主題 intraluminal administration
キーワード
主題Scheme Other
主題 methotrexate
キーワード
主題Scheme Other
主題 enterocolitis
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Sato, Nobuaki

× Sato, Nobuaki

WEKO 52702

Sato, Nobuaki

Search repository
Kanda, Tatsuo

× Kanda, Tatsuo

WEKO 52703

Kanda, Tatsuo

Search repository
Koyama, Yu

× Koyama, Yu

WEKO 52704

Koyama, Yu

Search repository
Kayama, Seiji

× Kayama, Seiji

WEKO 52705

Kayama, Seiji

Search repository
Ohkawa, Akira

× Ohkawa, Akira

WEKO 52706

Ohkawa, Akira

Search repository
Oyamatsu, Manabu

× Oyamatsu, Manabu

WEKO 52707

Oyamatsu, Manabu

Search repository
Hayashi, Mitsuhiro

× Hayashi, Mitsuhiro

WEKO 52708

Hayashi, Mitsuhiro

Search repository
Sato, Tomoi

× Sato, Tomoi

WEKO 52709

Sato, Tomoi

Search repository
Hatakeyama, Katsuyoshi

× Hatakeyama, Katsuyoshi

WEKO 52710

Hatakeyama, Katsuyoshi

Search repository
抄録
内容記述タイプ Abstract
内容記述 Background: Insulin-like growth factor-I (IGF-I) is a polypeptide hormone that is an important mediator of cellular growth, replication, and differentiation. IGF-I provides a major stimulus for enterocyte proliferation and the absorptive function. The aim of this study was to determine the effect of the intraluminal administration of IGF-I on the gastrointestinal tracts of rats with methotrexate (MTX)-induced enterocolitis. Study design: Male Sprague-Dawley rats weighing 140 to 205 g were intraperitoneally implanted with osmotic minipumps that delivered either 0.9% NaCl (saline group; n=8) or 10 nM IGF-I (IGF group; n= 9) to the ileal lumen through a short silastic catheter at a rate of 1μL/h. Rats received 20 mg/kg intraperitoneal MTX at the time of catheter insertion. Forty-eight hours after the MTX infusion, the small intestine was excised to measure mucosal protein and DNA content in jejunal and ileal segments. Additional measurements during the study period included changes in body weight and urinary nitrogen loss. Results: No significant difference in plasma IGF-I levels was seen between the groups. The saline group lost more body weight than the IGF group (p<0.05). In the IGF group, neither protein nor DNA content of the jejunum differed from those measured in the ileum. However, the ratio of the ileal to the jejunal protein content was significantly higher in the IGF group than in the saline group. Conclusion: Intraluminal administration of IGF-I may play a role in changing the distribution of gut mucosal proteins, in this rat model of MTX-induced enterocolitis.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 45, 号 3, p. 115-119, 発行日 1997-09
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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