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Effect of Intraluminal Administration of Insulin-like Growth Factor-I on Rats with Methotrexate-induced Enterocolitis
http://hdl.handle.net/10191/33129
http://hdl.handle.net/10191/33129e53b602a-e068-4554-bc2d-a4eef3960364
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
45(3)_115-119.pdf (826.5 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-08-25 | |||||
| タイトル | ||||||
| タイトル | Effect of Intraluminal Administration of Insulin-like Growth Factor-I on Rats with Methotrexate-induced Enterocolitis | |||||
| タイトル | ||||||
| タイトル | Effect of Intraluminal Administration of Insulin-like Growth Factor-I on Rats with Methotrexate-induced Enterocolitis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | insulin-like growth factor I | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | IGF-I | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | intraluminal administration | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | methotrexate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | enterocolitis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Sato, Nobuaki
× Sato, Nobuaki× Kanda, Tatsuo× Koyama, Yu× Kayama, Seiji× Ohkawa, Akira× Oyamatsu, Manabu× Hayashi, Mitsuhiro× Sato, Tomoi× Hatakeyama, Katsuyoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Insulin-like growth factor-I (IGF-I) is a polypeptide hormone that is an important mediator of cellular growth, replication, and differentiation. IGF-I provides a major stimulus for enterocyte proliferation and the absorptive function. The aim of this study was to determine the effect of the intraluminal administration of IGF-I on the gastrointestinal tracts of rats with methotrexate (MTX)-induced enterocolitis. Study design: Male Sprague-Dawley rats weighing 140 to 205 g were intraperitoneally implanted with osmotic minipumps that delivered either 0.9% NaCl (saline group; n=8) or 10 nM IGF-I (IGF group; n= 9) to the ileal lumen through a short silastic catheter at a rate of 1μL/h. Rats received 20 mg/kg intraperitoneal MTX at the time of catheter insertion. Forty-eight hours after the MTX infusion, the small intestine was excised to measure mucosal protein and DNA content in jejunal and ileal segments. Additional measurements during the study period included changes in body weight and urinary nitrogen loss. Results: No significant difference in plasma IGF-I levels was seen between the groups. The saline group lost more body weight than the IGF group (p<0.05). In the IGF group, neither protein nor DNA content of the jejunum differed from those measured in the ileum. However, the ratio of the ileal to the jejunal protein content was significantly higher in the IGF group than in the saline group. Conclusion: Intraluminal administration of IGF-I may play a role in changing the distribution of gut mucosal proteins, in this rat model of MTX-induced enterocolitis. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 45, 号 3, p. 115-119, 発行日 1997-09 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
