{"_buckets": {"deposit": "b3bea869-2d2f-432a-a31a-d547b5682674"}, "_deposit": {"id": "6388", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6388"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006388"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1997-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "151", "bibliographicPageStart": "143", "bibliographicVolumeNumber": "45", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Background: Endocrine cell tumors of the gastrointestinal tract are divided into the carinoid tumor (CD), a low-grade malignancy, and endocrine cell carcinoma (ECC), a high-grade malignancy. In this study, nuclear morphometry and proliferating cell nuclear antigen (PCNA) immunohistochemistry were performed to distinguish objectively between CDs and metastasizing CDs or ECCs. Methods: Nuclear morphometry and PCNA immunohistochemistry were performed on the following colorectal endocrine cell tumors: 15 primary CDs and 1 metastatic focus, 5 primary ECCs and 3 metastatic foci, and their counterparts of 5 solid adenocarcinomas and 3 metastatic lesions. To differentiate the tumors from one another and to elucidate which features are responsible for metastasis in CDs. Results: Nuclear morphometric values (area, circumference, and short diameter) significantly increased in the order of CDs, ECCs, and adenocarcinomas, and were positively correlated with the PCNA index (PI) and particularly with a PI of strongly positive cells (PI-S). The PI and PI-S significantly increased in the order of CDs, ECCs, and adenocarcinomas (p \u003c0.01). A 20.0 x 17.0 mm CD, which extended down into the muscle layer metastasized to the lymph nodes and liver, contained a high-grade atypical (HGA) area. The HGA area, 10.6 mm^2 located in the submucosa, showed nuclear morphometric values quite similar to those of a nodal metastatic lesion, and its PI and PI-S were significantly higher than in the remaining primary CD area, but lower than in ECCs. Conclusions: Nuclear morphometry and PCNA index are useful for distinguishing CDs from more malignant CDs or ECCs, and for detecting the progressive potentiality of CDs.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nishikura, Ken"}], "nameIdentifiers": [{"nameIdentifier": "52665", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Hidenobu"}], "nameIdentifiers": [{"nameIdentifier": "52666", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwafuchi, Mitsuya"}], "nameIdentifiers": [{"nameIdentifier": "52667", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "45(4)_143-151.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1600000.0, "url": {"label": "45(4)_143-151.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6388/files/45(4)_143-151.pdf"}, "version_id": "5c2d7701-cf5c-4dec-9193-658635a04f54"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "endocrine cell tumor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "carcinoid tumor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "endocrine cell carcinoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "large intestine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PCNA", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nuclear morphometry", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine"}, {"subitem_title": "PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/613"], "permalink_uri": "http://hdl.handle.net/10191/33134", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-08-25"}, "publish_date": "2015-08-25", "publish_status": "0", "recid": "6388", "relation": {}, "relation_version_is_last": true, "title": ["PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine"], "weko_shared_id": null}