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In this study, nuclear morphometry and proliferating cell nuclear antigen (PCNA) immunohistochemistry were performed to distinguish objectively between CDs and metastasizing CDs or ECCs. Methods: Nuclear morphometry and PCNA immunohistochemistry were performed on the following colorectal endocrine cell tumors: 15 primary CDs and 1 metastatic focus, 5 primary ECCs and 3 metastatic foci, and their counterparts of 5 solid adenocarcinomas and 3 metastatic lesions. To differentiate the tumors from one another and to elucidate which features are responsible for metastasis in CDs. Results: Nuclear morphometric values (area, circumference, and short diameter) significantly increased in the order of CDs, ECCs, and adenocarcinomas, and were positively correlated with the PCNA index (PI) and particularly with a PI of strongly positive cells (PI-S). The PI and PI-S significantly increased in the order of CDs, ECCs, and adenocarcinomas (p \u003c0.01). A 20.0 x 17.0 mm CD, which extended down into the muscle layer metastasized to the lymph nodes and liver, contained a high-grade atypical (HGA) area. The HGA area, 10.6 mm^2 located in the submucosa, showed nuclear morphometric values quite similar to those of a nodal metastatic lesion, and its PI and PI-S were significantly higher than in the remaining primary CD area, but lower than in ECCs. 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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.45 No.4

PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine

http://hdl.handle.net/10191/33134
http://hdl.handle.net/10191/33134
d09f95d6-6698-4459-9f30-7330f0752faa
名前 / ファイル ライセンス アクション
45(4)_143-151.pdf 45(4)_143-151.pdf (1.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-25
タイトル
タイトル PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine
タイトル
言語 en
タイトル PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine
言語
言語 eng
キーワード
主題Scheme Other
主題 endocrine cell tumor
キーワード
主題Scheme Other
主題 carcinoid tumor
キーワード
主題Scheme Other
主題 endocrine cell carcinoma
キーワード
主題Scheme Other
主題 large intestine
キーワード
主題Scheme Other
主題 PCNA
キーワード
主題Scheme Other
主題 nuclear morphometry
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Nishikura, Ken

× Nishikura, Ken

WEKO 52665

Nishikura, Ken

Search repository
Watanabe, Hidenobu

× Watanabe, Hidenobu

WEKO 52666

Watanabe, Hidenobu

Search repository
Iwafuchi, Mitsuya

× Iwafuchi, Mitsuya

WEKO 52667

Iwafuchi, Mitsuya

Search repository
抄録
内容記述タイプ Abstract
内容記述 Background: Endocrine cell tumors of the gastrointestinal tract are divided into the carinoid tumor (CD), a low-grade malignancy, and endocrine cell carcinoma (ECC), a high-grade malignancy. In this study, nuclear morphometry and proliferating cell nuclear antigen (PCNA) immunohistochemistry were performed to distinguish objectively between CDs and metastasizing CDs or ECCs. Methods: Nuclear morphometry and PCNA immunohistochemistry were performed on the following colorectal endocrine cell tumors: 15 primary CDs and 1 metastatic focus, 5 primary ECCs and 3 metastatic foci, and their counterparts of 5 solid adenocarcinomas and 3 metastatic lesions. To differentiate the tumors from one another and to elucidate which features are responsible for metastasis in CDs. Results: Nuclear morphometric values (area, circumference, and short diameter) significantly increased in the order of CDs, ECCs, and adenocarcinomas, and were positively correlated with the PCNA index (PI) and particularly with a PI of strongly positive cells (PI-S). The PI and PI-S significantly increased in the order of CDs, ECCs, and adenocarcinomas (p <0.01). A 20.0 x 17.0 mm CD, which extended down into the muscle layer metastasized to the lymph nodes and liver, contained a high-grade atypical (HGA) area. The HGA area, 10.6 mm^2 located in the submucosa, showed nuclear morphometric values quite similar to those of a nodal metastatic lesion, and its PI and PI-S were significantly higher than in the remaining primary CD area, but lower than in ECCs. Conclusions: Nuclear morphometry and PCNA index are useful for distinguishing CDs from more malignant CDs or ECCs, and for detecting the progressive potentiality of CDs.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 45, 号 4, p. 143-151, 発行日 1997-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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