{"created":"2021-03-01T06:10:17.529948+00:00","id":6388,"links":{},"metadata":{"_buckets":{"deposit":"b3bea869-2d2f-432a-a31a-d547b5682674"},"_deposit":{"id":"6388","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6388"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006388","sets":["453:456","471:537:568:613"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"151","bibliographicPageStart":"143","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Endocrine cell tumors of the gastrointestinal tract are divided into the carinoid tumor (CD), a low-grade malignancy, and endocrine cell carcinoma (ECC), a high-grade malignancy. In this study, nuclear morphometry and proliferating cell nuclear antigen (PCNA) immunohistochemistry were performed to distinguish objectively between CDs and metastasizing CDs or ECCs. Methods: Nuclear morphometry and PCNA immunohistochemistry were performed on the following colorectal endocrine cell tumors: 15 primary CDs and 1 metastatic focus, 5 primary ECCs and 3 metastatic foci, and their counterparts of 5 solid adenocarcinomas and 3 metastatic lesions. To differentiate the tumors from one another and to elucidate which features are responsible for metastasis in CDs. Results: Nuclear morphometric values (area, circumference, and short diameter) significantly increased in the order of CDs, ECCs, and adenocarcinomas, and were positively correlated with the PCNA index (PI) and particularly with a PI of strongly positive cells (PI-S). The PI and PI-S significantly increased in the order of CDs, ECCs, and adenocarcinomas (p <0.01). A 20.0 x 17.0 mm CD, which extended down into the muscle layer metastasized to the lymph nodes and liver, contained a high-grade atypical (HGA) area. The HGA area, 10.6 mm^2 located in the submucosa, showed nuclear morphometric values quite similar to those of a nodal metastatic lesion, and its PI and PI-S were significantly higher than in the remaining primary CD area, but lower than in ECCs. Conclusions: Nuclear morphometry and PCNA index are useful for distinguishing CDs from more malignant CDs or ECCs, and for detecting the progressive potentiality of CDs.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishikura, Ken"}],"nameIdentifiers":[{"nameIdentifier":"52665","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Hidenobu"}],"nameIdentifiers":[{"nameIdentifier":"52666","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwafuchi, Mitsuya"}],"nameIdentifiers":[{"nameIdentifier":"52667","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"45(4)_143-151.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"45(4)_143-151.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6388/files/45(4)_143-151.pdf"},"version_id":"5c2d7701-cf5c-4dec-9193-658635a04f54"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"endocrine cell tumor","subitem_subject_scheme":"Other"},{"subitem_subject":"carcinoid tumor","subitem_subject_scheme":"Other"},{"subitem_subject":"endocrine cell carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"large intestine","subitem_subject_scheme":"Other"},{"subitem_subject":"PCNA","subitem_subject_scheme":"Other"},{"subitem_subject":"nuclear morphometry","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine"},{"subitem_title":"PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","613"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-25"},"publish_date":"2015-08-25","publish_status":"0","recid":"6388","relation_version_is_last":true,"title":["PCNA Index and Nuclear Morphometry for Diagnosing Higher Malignancies of Endocrine Cell Tumors in the Large Intestine"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:42.613019+00:00"}