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Effects of Heat-killed E. coli Pretreatment on Agonist-induced Contractile Response of the Isolated Vas-deferens
http://hdl.handle.net/10191/33072
http://hdl.handle.net/10191/3307225a3ec9d-a8ab-429f-b7c2-1d839c15e1f3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46(1)_7-10.pdf (420.4 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-21 | |||||
| タイトル | ||||||
| タイトル | Effects of Heat-killed E. coli Pretreatment on Agonist-induced Contractile Response of the Isolated Vas-deferens | |||||
| タイトル | ||||||
| タイトル | Effects of Heat-killed E. coli Pretreatment on Agonist-induced Contractile Response of the Isolated Vas-deferens | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Heat-killed E. coli | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endotoxin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | vas-deferens | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | contractility | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
RB, Ashorobi
× RB, Ashorobi× FD, Braide× KD, Adesanya |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effect of noradrenaline (NA), acetylcholine (ACh) and 5-hydroxytryptamine (5-HT) on the contractility of the vas-deferens smooth muscle isolated from rats treated with heat-killed E. coli (endotoxin) was investigated. The contractile tension to these drugs was significantly decreased as compared with control values at different post-treatment time periods except for 5-HT at 48 h post treatment time. The 48 h tissues showed an increased sensitivity to 5-HT, while the same doses produced a decreased contractility in the 72 h tissues. The structural integrity of the vas deferens is vital in the ionic transport mechanism essential to ExcetationContraction coupling. E. coli induced a decreased responsiveness of the vas deferens to these mediators probably due to the liberation of free radicals. The latter itself could cause damage to the oxidizable muscle membrane structures or by a direct action on the membrane enzyme systems. Either of these postulates will interfere with smooth muscle contractility and thus impede the passage of spermatozoa to the testes in the septic state. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 46, 号 1, p. 7-10, 発行日 1998-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
RB, Ashorobi, FD, Braide, KD, Adesanya, 1998, Effects of Heat-killed E. coli Pretreatment on Agonist-induced Contractile Response of the Isolated Vas-deferens: Niigata University School of Medicine, 7–10 p.
