@article{oai:niigata-u.repo.nii.ac.jp:00006383,
 author = {RB, Ashorobi and FD, Braide and KD, Adesanya},
 issue = {1},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Mar},
 note = {The effect of noradrenaline (NA), acetylcholine (ACh) and 5-hydroxytryptamine (5-HT) on the contractility of the vas-deferens smooth muscle isolated from rats treated with heat-killed E. coli (endotoxin) was investigated. The contractile tension to these drugs was significantly decreased as compared with control values at different post-treatment time periods except for 5-HT at 48 h post treatment time. The 48 h tissues showed an increased sensitivity to 5-HT, while the same doses produced a decreased contractility in the 72 h tissues. The structural integrity of the vas deferens is vital in the ionic transport mechanism essential to ExcetationContraction coupling. E. coli induced a decreased responsiveness of the vas deferens to these mediators probably due to the liberation of free radicals. The latter itself could cause damage to the oxidizable muscle membrane structures or by a direct action on the membrane enzyme systems. Either of these postulates will interfere with smooth muscle contractility and thus impede the passage of spermatozoa to the testes in the septic state.},
 pages = {7--10},
 title = {Effects of Heat-killed E. coli Pretreatment on Agonist-induced Contractile Response of the Isolated Vas-deferens},
 volume = {46},
 year = {1998}
}