{"_buckets": {"deposit": "47e6e85f-343a-4056-8477-752ee885970f"}, "_deposit": {"id": "6375", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6375"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006375"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "46", "bibliographicPageStart": "39", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We investigated the cytotoxic activity of \u03b3\u03b4-receptor bearing T cells against glioma cells. Highly enriched \u03b3\u03b4-receptor bearing T cells were prepared from the peripheral blood mononuclear cells (PBMC) of three healthy donors and six patients with malignant glioma. After culturing with phytohemagglutinin and recombinant interleukin (rIL)- 2, 46-92% of PBMC came to bear the \u03b3\u03b4 T cell receptor, which hereafter shall be referred to as gamma delta riched (GDR) cells. GDR cells from one of the healthy donors showed a wide ranging killer activity against glioma cell lines as well as Raji cells. GDR cells which lysed autologous tumor cells also showed strong cytotoxic activities against the allogeneic glioma cell line U251 in a nonmajor histocompatibility complex restricted manner. The data suggest that \u03b3\u03b4 T cells from patients with malignant glioma could be used as new effector cells in adoptive immunotherapy for patients with malignant glioma.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Oda, Tazunu"}], "nameIdentifiers": [{"nameIdentifier": "52614", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "46(2)_39-46.pdf", "filesize": [{"value": "2.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2000000.0, "url": {"label": "46(2)_39-46.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6375/files/46(2)_39-46.pdf"}, "version_id": "1902588d-af56-42e2-926b-5eccdfe569c4"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "adoptive immunotherapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u03b3\u03b4 T cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "LAK cell", "subitem_subject_scheme": "Other"}, {"subitem_subject": "malignant glioma", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Activated Human \u03b3\u03b4 T Lymphocytes Exhibit Cytolytic Activity against Glioma Cells", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Activated Human \u03b3\u03b4 T Lymphocytes Exhibit Cytolytic Activity against Glioma Cells"}, {"subitem_title": "Activated Human \u03b3\u03b4 T Lymphocytes Exhibit Cytolytic Activity against Glioma Cells", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/611"], "permalink_uri": "http://hdl.handle.net/10191/33077", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-08-21"}, "publish_date": "2015-08-21", "publish_status": "0", "recid": "6375", "relation": {}, "relation_version_is_last": true, "title": ["Activated Human \u03b3\u03b4 T Lymphocytes Exhibit Cytolytic Activity against Glioma Cells"], "weko_shared_id": null}