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Activated Human γδ T Lymphocytes Exhibit Cytolytic Activity against Glioma Cells
http://hdl.handle.net/10191/33077
http://hdl.handle.net/10191/330773f01c205-5826-4667-92db-0d11abd175a6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46(2)_39-46.pdf (2.0 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-21 | |||||
| タイトル | ||||||
| タイトル | Activated Human γδ T Lymphocytes Exhibit Cytolytic Activity against Glioma Cells | |||||
| タイトル | ||||||
| タイトル | Activated Human γδ T Lymphocytes Exhibit Cytolytic Activity against Glioma Cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | adoptive immunotherapy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | γδ T cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | LAK cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | malignant glioma | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Oda, Tazunu
× Oda, Tazunu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We investigated the cytotoxic activity of γδ-receptor bearing T cells against glioma cells. Highly enriched γδ-receptor bearing T cells were prepared from the peripheral blood mononuclear cells (PBMC) of three healthy donors and six patients with malignant glioma. After culturing with phytohemagglutinin and recombinant interleukin (rIL)- 2, 46-92% of PBMC came to bear the γδ T cell receptor, which hereafter shall be referred to as gamma delta riched (GDR) cells. GDR cells from one of the healthy donors showed a wide ranging killer activity against glioma cell lines as well as Raji cells. GDR cells which lysed autologous tumor cells also showed strong cytotoxic activities against the allogeneic glioma cell line U251 in a nonmajor histocompatibility complex restricted manner. The data suggest that γδ T cells from patients with malignant glioma could be used as new effector cells in adoptive immunotherapy for patients with malignant glioma. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 46, 号 2, p. 39-46, 発行日 1998-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
