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Prevalence of Male Sex among Families with Sickle Cell Anemia
http://hdl.handle.net/10191/33088
http://hdl.handle.net/10191/33088167b8832-5685-4b8f-bd9f-fbcb07c69229
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46(3)_109-111.pdf (400.5 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-21 | |||||
| タイトル | ||||||
| タイトル | Prevalence of Male Sex among Families with Sickle Cell Anemia | |||||
| タイトル | ||||||
| タイトル | Prevalence of Male Sex among Families with Sickle Cell Anemia | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sex ratio | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sickle cell anemia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fetal hemoglobin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | acute hemolytic episodes | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Khaja, M. N.
× Khaja, M. N.× Vishnupriya, S.× Veerraju, P.× Habeebullah, C. M. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the present study the frequency of hemoglobin'S' was determined based on 10 tribal families and 31 non-tribal families of Andhra Pradesh, South India. The incidence of sickle cell anemia was found to be high in males as compared to females in both populations. Sickle cell trait remained more or less equal in both sexes. The gene frequency (q) of HbS was also predominantly high in males (0.231, 0.387 and 0.347) as compared with females (0.072, 0.297 and 0.241) in native, nonnative, and pooled sample' respectively. Sex ratio in HbSS individuals in both groups was found to be 2: 1, which showed a statistical significance, whereas no such deviation was observed in heterozygotes (SS). There was no significant relationship between parental genotypes or sex ratio among offspring. It is known that in acute anemic conditions, the chain synthesis is switched on to combat anoxic conditions due to a lowered hemoglobin level. We have estimated HbF levels in different genotypes, i. e. AA, AS & SS. The mean HhF levels were significantly elevated in SS genotype. This indicates that the γ chain synthesis is an alternative in acute hemolytic episodes due to the sickling. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 46, 号 3, p. 109-111, 発行日 1998-09 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
