@article{oai:niigata-u.repo.nii.ac.jp:00006373,
 author = {Khaja, M. N. and Vishnupriya, S. and Veerraju, P. and Habeebullah, C. M.},
 issue = {3},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Sep},
 note = {In the present study the frequency of hemoglobin'S' was determined based on 10 tribal families and 31 non-tribal families of Andhra Pradesh, South India. The incidence of sickle cell anemia was found to be high in males as compared to females in both populations. Sickle cell trait remained more or less equal in both sexes. The gene frequency (q) of HbS was also predominantly high in males (0.231, 0.387 and 0.347) as compared with females (0.072, 0.297 and 0.241) in native, nonnative, and pooled sample' respectively. Sex ratio in HbSS individuals in both groups was found to be 2: 1, which showed a statistical significance, whereas no such deviation was observed in heterozygotes (SS). There was no significant relationship between parental genotypes or sex ratio among offspring. It is known that in acute anemic conditions, the chain synthesis is switched on to combat anoxic conditions due to a lowered hemoglobin level. We have estimated HbF levels in different genotypes, i. e. AA, AS & SS. The mean HhF levels were significantly elevated in SS genotype. This indicates that the γ chain synthesis is an alternative in acute hemolytic episodes due to the sickling.},
 pages = {109--111},
 title = {Prevalence of Male Sex among Families with Sickle Cell Anemia},
 volume = {46},
 year = {1998}
}