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The Relationship between Arterial Plasma Potassium Concentration and Ventilation during Exercise in Patients with Chronic Obstructive Pulmonary Disease
http://hdl.handle.net/10191/33084
http://hdl.handle.net/10191/33084d6dc5562-81e6-485c-866b-79f680810547
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46(3)_81-87.pdf (675.1 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2015-08-21 | |||||
| タイトル | ||||||
| タイトル | The Relationship between Arterial Plasma Potassium Concentration and Ventilation during Exercise in Patients with Chronic Obstructive Pulmonary Disease | |||||
| タイトル | ||||||
| タイトル | The Relationship between Arterial Plasma Potassium Concentration and Ventilation during Exercise in Patients with Chronic Obstructive Pulmonary Disease | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | arterial plasma potassium | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | exercise hyperpnea | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hyperoxia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | chronic obstructive pulmonary disease | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Nakajima, Toshiaki
× Nakajima, Toshiaki× Ohdaira, Tetsuro× Satoh, Makoto× Kurashige, Kazuyuki× Yokota, Tatsuya× Suzuki, Eiichi× Kioi, Satoru× Arakawa, Masaaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study aims to elucidate the relationship between arterial plasma potassium concentration ([K^+]_a) and ventilation, and evaluate the effect of hyperoxia on the ventilation- [K^+]_a relationship during incremental exercise testing in patients with chronic obstructive pulmonary disease (COPD). We studied 16 male patients with COPD. Using a bicycle ergometer, each patient started to exercise with a work load of 25W, which was increased in steps of 5W in one minute intervals until the symptom-limited endpoint. The same trial with oxygen inhalation was also performed in 6 out of 16 patients. During the exercise testing in room air (n=16), [K^+]_a increased from the baseline (3.82 ± 0.18 mEq / L) to 4.62±0.33 mEq/L (p<0.01). Once exercise stopped, [K^+]_a decreased rapidly. In all patients, the increase in minute ventilation volume(V^^・_E) was significantly correlated with the elavation of [K^+]_a (p<0.05). Ventilatory response to [K^+]_a (the slope of △V_E/△K^+) varied markedly among the patients (13.1 to 50.7 L/min/mEq/L), and was correlated with forced vital capacity (FVC) (P< 0.05). During the trial with oxygen inhalation (n=6), the mean slope of △V^^・_E/△K^+ was not depressed, compared with the room air run, which was 21.9±11.9 in the former and 25.4±13.1 L/min/mEq/L in the latter, respectively. These findings indicate that: 1) ventilation and [K^+]_ a were correlated during exercise; 2) the slope of ventilatory response to [K^+]_a differed markedly among the patients, and was correlated with FVC; and 3) hyperoxia did not significantly affect the ventilation[K^+]_a relationship. We conclude that, while [K^+]_a may play some role, certain unknown factors may also be involved in determining the degree of exercise hyperpnea in patients with COPD. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 46, 号 3, p. 81-87, 発行日 1998-09 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
