{"_buckets": {"deposit": "ab3dc2b6-a97c-4b74-8b42-8a32b4fd2ea4"}, "_deposit": {"id": "6364", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6364"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006364"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "138", "bibliographicPageStart": "133", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The purpose of the present study was to evaluate the effects of nicardipine (NIC), nitroglycerin (NTG), and prostaglandin E_1 (PGE_1) on cerebrovascular CO_2 reactivity during propofol-fentanyl anesthesia in humans. Cerebrovascular CO_2 reactivity was evaluated with transcranial Doppler sonography (TCD) in 30 patients. The patients were randomly allocated to NIC, NTG or PGE_1 groups. Anesthesia was induced and maintained with a bolus, followed by a continuous infusion of propofol (6.73\u00b10.45 mg/kg/hr) and fentanyl (1.72\u00b10.54 ,\u03bcg/kg/hr). Time-mean blood flow velocity in the right middle cerebral artery (Vmca) was measured with TCD at an end-tidal CO_2 tension (P_\u003cET\u003eC0_2 ) of 50, 45, 40, 35, 30, and 25 mmHg during normotension and hypotension. Induced hypotension of mean arterial pressure 55-60 mmHg was maintained with a continuous infusion of NIC (6.99\u00b10.73 ,\u03bcg/kg/min), NTG (2.98\u00b11.10 ,\u03bcg/kg/min) or PGE_1 (0.103\u00b10.052 \u03bcg/kg/ min). The CO_2 reactivity of Vmca was determined by linear or exponential regression analysis and was compared between normotension and induced hypotension with repeated measures ANOVA. There was a significant close linear and exponential regression between Vmca and P_\u003cET\u003eCO_2 during normotension and hypotension in each subject (r \u003e0.95, p \u003c0.05). Absolute slopes and exponents were significantly attenuated during drug-induced hypotension, when compared with normotension (p \u003c0.05). These results strongly suggest that the cerebrovascular CO_2 reactivity is preserved. However, the cerebrovascular sensitivity to CO_2 is attenuated during NIC, NTG, and PGE_1-induced hypotension.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Endoh, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "52558", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Honda, Tadayuki"}], "nameIdentifiers": [{"nameIdentifier": "52559", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komura, Noboru"}], "nameIdentifiers": [{"nameIdentifier": "52560", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibue, Chieko"}], "nameIdentifiers": [{"nameIdentifier": "52561", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "46(4)_133-138.pdf", "filesize": [{"value": "605.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 605100.0, "url": {"label": "46(4)_133-138.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6364/files/46(4)_133-138.pdf"}, "version_id": "f9b6a2c0-82f9-4573-b18c-cdf3015d834a"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "induced hypotension", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cerebrovascular CO_2 reactivity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "transcranial Doppler ultrasonography", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans"}, {"subitem_title": "Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/609"], "permalink_uri": "http://hdl.handle.net/10191/33091", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2015-08-21"}, "publish_date": "2015-08-21", "publish_status": "0", "recid": "6364", "relation": {}, "relation_version_is_last": true, "title": ["Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans"], "weko_shared_id": null}