WEKO3
アイテム
Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans
http://hdl.handle.net/10191/33091
http://hdl.handle.net/10191/33091d30cc70b-34bd-45cb-ab68-6526358894db
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
46(4)_133-138.pdf (605.1 kB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-21 | |||||
| タイトル | ||||||
| タイトル | Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans | |||||
| タイトル | ||||||
| タイトル | Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | induced hypotension | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cerebrovascular CO_2 reactivity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | transcranial Doppler ultrasonography | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Endoh, Hiroshi
× Endoh, Hiroshi× Honda, Tadayuki× Komura, Noboru× Shibue, Chieko |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The purpose of the present study was to evaluate the effects of nicardipine (NIC), nitroglycerin (NTG), and prostaglandin E_1 (PGE_1) on cerebrovascular CO_2 reactivity during propofol-fentanyl anesthesia in humans. Cerebrovascular CO_2 reactivity was evaluated with transcranial Doppler sonography (TCD) in 30 patients. The patients were randomly allocated to NIC, NTG or PGE_1 groups. Anesthesia was induced and maintained with a bolus, followed by a continuous infusion of propofol (6.73±0.45 mg/kg/hr) and fentanyl (1.72±0.54 ,μg/kg/hr). Time-mean blood flow velocity in the right middle cerebral artery (Vmca) was measured with TCD at an end-tidal CO_2 tension (P_<ET>C0_2 ) of 50, 45, 40, 35, 30, and 25 mmHg during normotension and hypotension. Induced hypotension of mean arterial pressure 55-60 mmHg was maintained with a continuous infusion of NIC (6.99±0.73 ,μg/kg/min), NTG (2.98±1.10 ,μg/kg/min) or PGE_1 (0.103±0.052 μg/kg/ min). The CO_2 reactivity of Vmca was determined by linear or exponential regression analysis and was compared between normotension and induced hypotension with repeated measures ANOVA. There was a significant close linear and exponential regression between Vmca and P_<ET>CO_2 during normotension and hypotension in each subject (r >0.95, p <0.05). Absolute slopes and exponents were significantly attenuated during drug-induced hypotension, when compared with normotension (p <0.05). These results strongly suggest that the cerebrovascular CO_2 reactivity is preserved. However, the cerebrovascular sensitivity to CO_2 is attenuated during NIC, NTG, and PGE_1-induced hypotension. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 46, 号 4, p. 133-138, 発行日 1998-12 |
|||||
| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
