ログイン
言語:

WEKO3

  • トップ
  • ランキング
To

Field does not validate

To

Field does not validate

To
lat lon distance


インデックスリンク

インデックスツリー

  • RootNode

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.46 No.4

Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans

http://hdl.handle.net/10191/33091
http://hdl.handle.net/10191/33091
d30cc70b-34bd-45cb-ab68-6526358894db
名前 / ファイル ライセンス アクション
46(4)_133-138.pdf 46(4)_133-138.pdf (605.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2015-08-21
タイトル
タイトル Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans
タイトル
タイトル Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 induced hypotension
キーワード
主題Scheme Other
主題 cerebrovascular CO_2 reactivity
キーワード
主題Scheme Other
主題 transcranial Doppler ultrasonography
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Endoh, Hiroshi

× Endoh, Hiroshi

WEKO 52558

Endoh, Hiroshi

Search repository
Honda, Tadayuki

× Honda, Tadayuki

WEKO 52559

Honda, Tadayuki

Search repository
Komura, Noboru

× Komura, Noboru

WEKO 52560

Komura, Noboru

Search repository
Shibue, Chieko

× Shibue, Chieko

WEKO 52561

Shibue, Chieko

Search repository
抄録
内容記述タイプ Abstract
内容記述 The purpose of the present study was to evaluate the effects of nicardipine (NIC), nitroglycerin (NTG), and prostaglandin E_1 (PGE_1) on cerebrovascular CO_2 reactivity during propofol-fentanyl anesthesia in humans. Cerebrovascular CO_2 reactivity was evaluated with transcranial Doppler sonography (TCD) in 30 patients. The patients were randomly allocated to NIC, NTG or PGE_1 groups. Anesthesia was induced and maintained with a bolus, followed by a continuous infusion of propofol (6.73±0.45 mg/kg/hr) and fentanyl (1.72±0.54 ,μg/kg/hr). Time-mean blood flow velocity in the right middle cerebral artery (Vmca) was measured with TCD at an end-tidal CO_2 tension (P_<ET>C0_2 ) of 50, 45, 40, 35, 30, and 25 mmHg during normotension and hypotension. Induced hypotension of mean arterial pressure 55-60 mmHg was maintained with a continuous infusion of NIC (6.99±0.73 ,μg/kg/min), NTG (2.98±1.10 ,μg/kg/min) or PGE_1 (0.103±0.052 μg/kg/ min). The CO_2 reactivity of Vmca was determined by linear or exponential regression analysis and was compared between normotension and induced hypotension with repeated measures ANOVA. There was a significant close linear and exponential regression between Vmca and P_<ET>CO_2 during normotension and hypotension in each subject (r >0.95, p <0.05). Absolute slopes and exponents were significantly attenuated during drug-induced hypotension, when compared with normotension (p <0.05). These results strongly suggest that the cerebrovascular CO_2 reactivity is preserved. However, the cerebrovascular sensitivity to CO_2 is attenuated during NIC, NTG, and PGE_1-induced hypotension.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 46, 号 4, p. 133-138, 発行日 1998-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 19:40:36.208637
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

Endoh, Hiroshi, Honda, Tadayuki, Komura, Noboru, Shibue, Chieko, 1998, Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans: Niigata University School of Medicine, 133–138 p.

Loading...

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3