{"created":"2021-03-01T06:10:16.030717+00:00","id":6364,"links":{},"metadata":{"_buckets":{"deposit":"ab3dc2b6-a97c-4b74-8b42-8a32b4fd2ea4"},"_deposit":{"id":"6364","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6364"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006364","sets":["453:456","471:537:568:609"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"138","bibliographicPageStart":"133","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The purpose of the present study was to evaluate the effects of nicardipine (NIC), nitroglycerin (NTG), and prostaglandin E_1 (PGE_1) on cerebrovascular CO_2 reactivity during propofol-fentanyl anesthesia in humans. Cerebrovascular CO_2 reactivity was evaluated with transcranial Doppler sonography (TCD) in 30 patients. The patients were randomly allocated to NIC, NTG or PGE_1 groups. Anesthesia was induced and maintained with a bolus, followed by a continuous infusion of propofol (6.73±0.45 mg/kg/hr) and fentanyl (1.72±0.54 ,μg/kg/hr). Time-mean blood flow velocity in the right middle cerebral artery (Vmca) was measured with TCD at an end-tidal CO_2 tension (P_<ET>C0_2 ) of 50, 45, 40, 35, 30, and 25 mmHg during normotension and hypotension. Induced hypotension of mean arterial pressure 55-60 mmHg was maintained with a continuous infusion of NIC (6.99±0.73 ,μg/kg/min), NTG (2.98±1.10 ,μg/kg/min) or PGE_1 (0.103±0.052 μg/kg/ min). The CO_2 reactivity of Vmca was determined by linear or exponential regression analysis and was compared between normotension and induced hypotension with repeated measures ANOVA. There was a significant close linear and exponential regression between Vmca and P_<ET>CO_2 during normotension and hypotension in each subject (r >0.95, p <0.05). Absolute slopes and exponents were significantly attenuated during drug-induced hypotension, when compared with normotension (p <0.05). These results strongly suggest that the cerebrovascular CO_2 reactivity is preserved. However, the cerebrovascular sensitivity to CO_2 is attenuated during NIC, NTG, and PGE_1-induced hypotension.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Endoh, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"52558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Honda, Tadayuki"}],"nameIdentifiers":[{"nameIdentifier":"52559","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komura, Noboru"}],"nameIdentifiers":[{"nameIdentifier":"52560","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibue, Chieko"}],"nameIdentifiers":[{"nameIdentifier":"52561","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"46(4)_133-138.pdf","filesize":[{"value":"605.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"46(4)_133-138.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6364/files/46(4)_133-138.pdf"},"version_id":"f9b6a2c0-82f9-4573-b18c-cdf3015d834a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"induced hypotension","subitem_subject_scheme":"Other"},{"subitem_subject":"cerebrovascular CO_2 reactivity","subitem_subject_scheme":"Other"},{"subitem_subject":"transcranial Doppler ultrasonography","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans"},{"subitem_title":"Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","609"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-21"},"publish_date":"2015-08-21","publish_status":"0","recid":"6364","relation_version_is_last":true,"title":["Effects of Induced Hypotension on Cerebral Vasomotor Response to Carbon Dioxide in Humans"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:40.982187+00:00"}