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The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient
http://hdl.handle.net/10191/1929
http://hdl.handle.net/10191/1929fbff94c9-8c58-4217-b073-b62c242484be
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000007206.pdf (4.9 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient | |||||
| タイトル | ||||||
| タイトル | The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | spleen cell transfer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | success or failure in adoptive immunity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ehrlich tumor | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
SATO, Norimitsu L.
× SATO, Norimitsu L.× KATO, Akiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It has been shown that adoptive immune transfer in mice for Ehrlich ascites tumors (EAT) is successful in a genetically defined combination such as B6 as donor and B6-nu/nu as recipient. Among allogeneic mouse strains, the adoptive immune transfer was rarely successful with a few exceptions. To observe the mechanism, the fate of intraperitoneally transferred donor spleen cells in the recipients was monitored by staining the cells with fluorescent PKH-26 dye, and using some typical donor and recipient combinations. The results are as follows. Spleen cells from B6-Ly-2^a, 3^a mice were very effective in suppressing subcutaneous EAT outgrowth in B6-nu/nu mice but not in DBA/1 or in ddY-drm. Spleen cells of B6-Ly-2^a, 3^a mice were alive and infiltrated everywhere in B6-nu/nu mice. Some of the effector cells both reached and made contact with EAT cells and lethally affected the tumor cells. Accordingly, EAT outgrowth in B6-nu/nu mice was remarkably suppressed and no solid tumor formation was recognized. On the other hand, spleen cells from B6-Ly-2^a, 3^a mice were killed at an early stage by peritoneal macrophages in the recipients in DBA/1 or in ddY-prg mice, and they did no reach the EAT site. As a result, subcutaneous EAT progressed gradually and formed a solid tumor. The spleen cells of B6-Ly-2^a, 3^a mice which were subcutaneously inoculated into the recipients in a mixture form with EAT cells were sufficiently active for suppressing EAT outgrowth both in DBA/1 and ddY-prg mice. From the results, it is concluded that the contact of donor spleen cells with EAT cells in the recipient without any disturbance is highly important in producing a suppressive effect on EAT in vivo. At an early stage in the spleen cell transfer, recipient macrophage activity is the first barrier to the effective donor cells transferred. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 47, 号 2, p. 67-74, 発行日 1999-06 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
