{"_buckets": {"deposit": "7c03d8c6-0f7d-433f-957b-2b29a2c4c02c"}, "_deposit": {"id": "6354", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6354"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006354"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1999-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "74", "bibliographicPageStart": "67", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "It has been shown that adoptive immune transfer in mice for Ehrlich ascites tumors (EAT) is successful in a genetically defined combination such as B6 as donor and B6-nu/nu as recipient. Among allogeneic mouse strains, the adoptive immune transfer was rarely successful with a few exceptions. To observe the mechanism, the fate of intraperitoneally transferred donor spleen cells in the recipients was monitored by staining the cells with fluorescent PKH-26 dye, and using some typical donor and recipient combinations. The results are as follows. Spleen cells from B6-Ly-2^a, 3^a mice were very effective in suppressing subcutaneous EAT outgrowth in B6-nu/nu mice but not in DBA/1 or in ddY-drm. Spleen cells of B6-Ly-2^a, 3^a mice were alive and infiltrated everywhere in B6-nu/nu mice. Some of the effector cells both reached and made contact with EAT cells and lethally affected the tumor cells. Accordingly, EAT outgrowth in B6-nu/nu mice was remarkably suppressed and no solid tumor formation was recognized. On the other hand, spleen cells from B6-Ly-2^a, 3^a mice were killed at an early stage by peritoneal macrophages in the recipients in DBA/1 or in ddY-prg mice, and they did no reach the EAT site. As a result, subcutaneous EAT progressed gradually and formed a solid tumor. The spleen cells of B6-Ly-2^a, 3^a mice which were subcutaneously inoculated into the recipients in a mixture form with EAT cells were sufficiently active for suppressing EAT outgrowth both in DBA/1 and ddY-prg mice. From the results, it is concluded that the contact of donor spleen cells with EAT cells in the recipient without any disturbance is highly important in producing a suppressive effect on EAT in vivo. At an early stage in the spleen cell transfer, recipient macrophage activity is the first barrier to the effective donor cells transferred.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "SATO, Norimitsu L."}], "nameIdentifiers": [{"nameIdentifier": "52518", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KATO, Akiko"}], "nameIdentifiers": [{"nameIdentifier": "52519", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000007206.pdf", "filesize": [{"value": "4.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 4900000.0, "url": {"label": "KJ00000007206.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6354/files/KJ00000007206.pdf"}, "version_id": "8c1be2b1-7d8e-4ee9-92f9-cf823a7bda30"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "spleen cell transfer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "success or failure in adoptive immunity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ehrlich tumor", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient"}, {"subitem_title": "The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/607"], "permalink_uri": "http://hdl.handle.net/10191/1929", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6354", "relation": {}, "relation_version_is_last": true, "title": ["The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient"], "weko_shared_id": null}