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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.47 No.2

The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient

http://hdl.handle.net/10191/1929
http://hdl.handle.net/10191/1929
fbff94c9-8c58-4217-b073-b62c242484be
名前 / ファイル ライセンス アクション
KJ00000007206.pdf KJ00000007206.pdf (4.9 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient
タイトル
タイトル The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 spleen cell transfer
キーワード
主題Scheme Other
主題 success or failure in adoptive immunity
キーワード
主題Scheme Other
主題 Ehrlich tumor
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 SATO, Norimitsu L.

× SATO, Norimitsu L.

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SATO, Norimitsu L.

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KATO, Akiko

× KATO, Akiko

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KATO, Akiko

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抄録
内容記述タイプ Abstract
内容記述 It has been shown that adoptive immune transfer in mice for Ehrlich ascites tumors (EAT) is successful in a genetically defined combination such as B6 as donor and B6-nu/nu as recipient. Among allogeneic mouse strains, the adoptive immune transfer was rarely successful with a few exceptions. To observe the mechanism, the fate of intraperitoneally transferred donor spleen cells in the recipients was monitored by staining the cells with fluorescent PKH-26 dye, and using some typical donor and recipient combinations. The results are as follows. Spleen cells from B6-Ly-2^a, 3^a mice were very effective in suppressing subcutaneous EAT outgrowth in B6-nu/nu mice but not in DBA/1 or in ddY-drm. Spleen cells of B6-Ly-2^a, 3^a mice were alive and infiltrated everywhere in B6-nu/nu mice. Some of the effector cells both reached and made contact with EAT cells and lethally affected the tumor cells. Accordingly, EAT outgrowth in B6-nu/nu mice was remarkably suppressed and no solid tumor formation was recognized. On the other hand, spleen cells from B6-Ly-2^a, 3^a mice were killed at an early stage by peritoneal macrophages in the recipients in DBA/1 or in ddY-prg mice, and they did no reach the EAT site. As a result, subcutaneous EAT progressed gradually and formed a solid tumor. The spleen cells of B6-Ly-2^a, 3^a mice which were subcutaneously inoculated into the recipients in a mixture form with EAT cells were sufficiently active for suppressing EAT outgrowth both in DBA/1 and ddY-prg mice. From the results, it is concluded that the contact of donor spleen cells with EAT cells in the recipient without any disturbance is highly important in producing a suppressive effect on EAT in vivo. At an early stage in the spleen cell transfer, recipient macrophage activity is the first barrier to the effective donor cells transferred.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 47, 号 2, p. 67-74, 発行日 1999-06
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
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