{"created":"2021-03-01T06:10:15.408331+00:00","id":6354,"links":{},"metadata":{"_buckets":{"deposit":"7c03d8c6-0f7d-433f-957b-2b29a2c4c02c"},"_deposit":{"id":"6354","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6354"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006354","sets":["453:456","471:537:568:607"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"74","bibliographicPageStart":"67","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It has been shown that adoptive immune transfer in mice for Ehrlich ascites tumors (EAT) is successful in a genetically defined combination such as B6 as donor and B6-nu/nu as recipient. Among allogeneic mouse strains, the adoptive immune transfer was rarely successful with a few exceptions. To observe the mechanism, the fate of intraperitoneally transferred donor spleen cells in the recipients was monitored by staining the cells with fluorescent PKH-26 dye, and using some typical donor and recipient combinations. The results are as follows. Spleen cells from B6-Ly-2^a, 3^a mice were very effective in suppressing subcutaneous EAT outgrowth in B6-nu/nu mice but not in DBA/1 or in ddY-drm. Spleen cells of B6-Ly-2^a, 3^a mice were alive and infiltrated everywhere in B6-nu/nu mice. Some of the effector cells both reached and made contact with EAT cells and lethally affected the tumor cells. Accordingly, EAT outgrowth in B6-nu/nu mice was remarkably suppressed and no solid tumor formation was recognized. On the other hand, spleen cells from B6-Ly-2^a, 3^a mice were killed at an early stage by peritoneal macrophages in the recipients in DBA/1 or in ddY-prg mice, and they did no reach the EAT site. As a result, subcutaneous EAT progressed gradually and formed a solid tumor. The spleen cells of B6-Ly-2^a, 3^a mice which were subcutaneously inoculated into the recipients in a mixture form with EAT cells were sufficiently active for suppressing EAT outgrowth both in DBA/1 and ddY-prg mice. From the results, it is concluded that the contact of donor spleen cells with EAT cells in the recipient without any disturbance is highly important in producing a suppressive effect on EAT in vivo. At an early stage in the spleen cell transfer, recipient macrophage activity is the first barrier to the effective donor cells transferred.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SATO, Norimitsu L."}],"nameIdentifiers":[{"nameIdentifier":"52518","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KATO, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"52519","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"KJ00000007206.pdf","filesize":[{"value":"4.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000007206.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6354/files/KJ00000007206.pdf"},"version_id":"8c1be2b1-7d8e-4ee9-92f9-cf823a7bda30"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"spleen cell transfer","subitem_subject_scheme":"Other"},{"subitem_subject":"success or failure in adoptive immunity","subitem_subject_scheme":"Other"},{"subitem_subject":"Ehrlich tumor","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient"},{"subitem_title":"The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","607"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"6354","relation_version_is_last":true,"title":["The Efficiency of Adoptive Immunotherapy for Ehrlich Tumors in Miceand Fate of the Transferred Spleen Cells in the Recipient"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:38.929467+00:00"}