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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.47 No.4

Renal Hemodynamic Characteristics and Their Correlation with Serum Autoantibodies in Patients with Systemic Sclerosis

http://hdl.handle.net/10191/1873
http://hdl.handle.net/10191/1873
a70d5662-29e1-4182-9aeb-b5d58dea81b2
名前 / ファイル ライセンス アクション
KJ00000007228.pdf KJ00000007228.pdf (3.9 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Renal Hemodynamic Characteristics and Their Correlation with Serum Autoantibodies in Patients with Systemic Sclerosis
タイトル
言語 en
タイトル Renal Hemodynamic Characteristics and Their Correlation with Serum Autoantibodies in Patients with Systemic Sclerosis
言語
言語 eng
キーワード
主題Scheme Other
主題 systemic sclerosis
キーワード
主題Scheme Other
主題 renal hemodynamics
キーワード
主題Scheme Other
主題 anti-DNA topoisomerase 1 antibody
キーワード
主題Scheme Other
主題 anti-centromere antibody
キーワード
主題Scheme Other
主題 renal plasma flow
キーワード
主題Scheme Other
主題 filtration fraction
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 NAKANO, Masaaki

× NAKANO, Masaaki

WEKO 52462

NAKANO, Masaaki

Search repository
OHUCHI, Yuko

× OHUCHI, Yuko

WEKO 52463

OHUCHI, Yuko

Search repository
HASEGAWA, Hisashi

× HASEGAWA, Hisashi

WEKO 52464

HASEGAWA, Hisashi

Search repository
KURODA, Takeshi

× KURODA, Takeshi

WEKO 52465

KURODA, Takeshi

Search repository
ITO, Satoshi

× ITO, Satoshi

WEKO 52466

ITO, Satoshi

Search repository
ARAKAWA, Masaaki

× ARAKAWA, Masaaki

WEKO 52467

ARAKAWA, Masaaki

Search repository
抄録
内容記述タイプ Abstract
内容記述 To clarify the characteristics of renal hemodynamics and their correlation with serum autoantibodies in patients with systemic sclerosis (SSc). Methods : Glomerular filtration rate (GFR) and renal plasma flow (RPF) were analyzed retrospectively in three groups totaling 50 Japanese patients with SSc treated between 1982 and 1998. The filtration fraction (FF) was calculated from the values obtained for GFR and RPF (GFR/RPF). The presence of antibodies to DNA topoisomerase 1 (A-Topo) and centromere (ACA) were also examined in relation to renal hemodynamics. Results : The GFR was abnormally low in 8 (16.0%) patients, but a decreased RPF was observed in 21 (42.0%). Thus, an increased FF was frequently observed (29/50; 58.0%). A-Topo was detected in 23 patients (group A) and ACA in 10 (group B). In the remaining 17 patients (group C), however, these autoantibodies were not detected. Diffuse scleroderma or pulmonary fibrosis was more prevalent in group A than in group B. The mean GFR in group B was significantly lower than that in group C. The mean RPF in group B was significantly lower than that in the other 2 groups. Patients with an increased FF were more often found in group B than in the other 2 groups. Conclusions : A reduction in RPF disproportionate to the reduction in GFR, as demonstrated by the high FF, was observed frequently in SSc patients. Although ACA was associated with less serious cutaneous or pulmonary involvement, renal hemodynamic alterations seemed to correlate with the presence of ACA.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 47, 号 4, p. 155-159, 発行日 1999-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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