@article{oai:niigata-u.repo.nii.ac.jp:00006342,
 author = {NAKANO, Masaaki and OHUCHI, Yuko and HASEGAWA, Hisashi and KURODA, Takeshi and ITO, Satoshi and ARAKAWA, Masaaki},
 issue = {4},
 journal = {Acta medica et biologica, Acta medica et biologica},
 month = {Dec},
 note = {To clarify the characteristics of renal hemodynamics and their correlation with serum autoantibodies in patients with systemic sclerosis (SSc). Methods : Glomerular filtration rate (GFR) and renal plasma flow (RPF) were analyzed retrospectively in three groups totaling 50 Japanese patients with SSc treated between 1982 and 1998. The filtration fraction (FF) was calculated from the values obtained for GFR and RPF (GFR/RPF). The presence of antibodies to DNA topoisomerase 1 (A-Topo) and centromere (ACA) were also examined in relation to renal hemodynamics. Results : The GFR was abnormally low in 8 (16.0%) patients, but a decreased RPF was observed in 21 (42.0%). Thus, an increased FF was frequently observed (29/50; 58.0%). A-Topo was detected in 23 patients (group A) and ACA in 10 (group B). In the remaining 17 patients (group C), however, these autoantibodies were not detected. Diffuse scleroderma or pulmonary fibrosis was more prevalent in group A than in group B. The mean GFR in group B was significantly lower than that in group C. The mean RPF in group B was significantly lower than that in the other 2 groups. Patients with an increased FF were more often found in group B than in the other 2 groups. Conclusions : A reduction in RPF disproportionate to the reduction in GFR, as demonstrated by the high FF, was observed frequently in SSc patients. Although ACA was associated with less serious cutaneous or pulmonary involvement, renal hemodynamic alterations seemed to correlate with the presence of ACA.},
 pages = {155--159},
 title = {Renal Hemodynamic Characteristics and Their Correlation with Serum Autoantibodies in Patients with Systemic Sclerosis},
 volume = {47},
 year = {1999}
}