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Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity
http://hdl.handle.net/10191/1861
http://hdl.handle.net/10191/18618689c853-271f-4524-a139-8b8467d43261
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-10 | |||||
タイトル | ||||||
タイトル | Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lipid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | insulin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apolipoprotein | |||||
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主題Scheme | Other | |||||
主題 | fat | |||||
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主題Scheme | Other | |||||
主題 | polymerase chain reaction | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
KIKUCHI, Toru
× KIKUCHI, Toru× HASHIMOTO, Naoshi× KAWASAKI, Takuya× OKUGAWA, Takayoshi× UCHIYAMA, Makoto |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Genetic factors of obesity that have recently been revealed include the β3-adrenergic receptor (β3AR) gene. The aim of this study is to examine the possible role in childhood obesity of a mutation in the β3AR gene. This study examined 72,139,and 48 Japanese obese children at 7,10,and 13 years of age, respectively. Polymorphism in the β3AR gene was analyzed using a polymerase chain reaction and the restriction enzyme of BstNI as well as serum levels of lipids and insulin in fasting blood samples. Analyses revealed seven Arg64 homozygotes, 101 Trp64/Arg64 heterozygotes, and 151 Trp64 homozygotes. Seven-year-old subjects with the mutation (n=27) had a larger relative weight (154.8±10.6%), higher ponderal index (kg/m^3) (19.0±1.3), and higher levels of triglyceride (95.6±46.0 mg/dl) and insulin (9.3±3.0μ U/ml) than those without the mutation (n=45) (149.3±8.9%, 18.3±1.1,74.8±31.4mg/dl, and 7.6±2.5μU/ml, respectively, p<0.05). In either 10 or 13-year-old, no significant differences were observed in the above mentioned parameters between subjects with or without the mutation. These results suggest that a polymorphism in the β3AR gene contributes to obesity and is associated with hyperinsulinemia and hypertriglyceridemia in younger obese children. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 48, 号 4, p. 135-139, 発行日 2000-12 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |