WEKO3
アイテム
{"_buckets": {"deposit": "03d10fdc-07f8-4eca-91fa-549dd6b53505"}, "_deposit": {"id": "6319", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6319"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006319", "sets": ["456", "601"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2000-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "139", "bibliographicPageStart": "135", "bibliographicVolumeNumber": "48", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Genetic factors of obesity that have recently been revealed include the β3-adrenergic receptor (β3AR) gene. The aim of this study is to examine the possible role in childhood obesity of a mutation in the β3AR gene. This study examined 72,139,and 48 Japanese obese children at 7,10,and 13 years of age, respectively. Polymorphism in the β3AR gene was analyzed using a polymerase chain reaction and the restriction enzyme of BstNI as well as serum levels of lipids and insulin in fasting blood samples. Analyses revealed seven Arg64 homozygotes, 101 Trp64/Arg64 heterozygotes, and 151 Trp64 homozygotes. Seven-year-old subjects with the mutation (n=27) had a larger relative weight (154.8±10.6%), higher ponderal index (kg/m^3) (19.0±1.3), and higher levels of triglyceride (95.6±46.0 mg/dl) and insulin (9.3±3.0μ U/ml) than those without the mutation (n=45) (149.3±8.9%, 18.3±1.1,74.8±31.4mg/dl, and 7.6±2.5μU/ml, respectively, p\u003c0.05). In either 10 or 13-year-old, no significant differences were observed in the above mentioned parameters between subjects with or without the mutation. These results suggest that a polymorphism in the β3AR gene contributes to obesity and is associated with hyperinsulinemia and hypertriglyceridemia in younger obese children.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "KIKUCHI, Toru"}], "nameIdentifiers": [{"nameIdentifier": "52326", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HASHIMOTO, Naoshi"}], "nameIdentifiers": [{"nameIdentifier": "52327", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAWASAKI, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "52328", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OKUGAWA, Takayoshi"}], "nameIdentifiers": [{"nameIdentifier": "52329", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "UCHIYAMA, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "52330", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000007274.pdf", "filesize": [{"value": "2.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2100000.0, "url": {"label": "KJ00000007274.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6319/files/KJ00000007274.pdf"}, "version_id": "8017d587-82f8-4b31-b9d8-8791b3676c52"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "lipid", "subitem_subject_scheme": "Other"}, {"subitem_subject": "insulin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "apolipoprotein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fat", "subitem_subject_scheme": "Other"}, {"subitem_subject": "polymerase chain reaction", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity"}, {"subitem_title": "Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "601"], "permalink_uri": "http://hdl.handle.net/10191/1861", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6319", "relation": {}, "relation_version_is_last": true, "title": ["Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity"], "weko_shared_id": null}
Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity
http://hdl.handle.net/10191/1861
http://hdl.handle.net/10191/18618689c853-271f-4524-a139-8b8467d43261
名前 / ファイル | ライセンス | アクション |
---|---|---|
KJ00000007274.pdf (2.1 MB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2007-05-10 | |||||
タイトル | ||||||
タイトル | Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lipid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | insulin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apolipoprotein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | polymerase chain reaction | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
KIKUCHI, Toru
× KIKUCHI, Toru× HASHIMOTO, Naoshi× KAWASAKI, Takuya× OKUGAWA, Takayoshi× UCHIYAMA, Makoto |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Genetic factors of obesity that have recently been revealed include the β3-adrenergic receptor (β3AR) gene. The aim of this study is to examine the possible role in childhood obesity of a mutation in the β3AR gene. This study examined 72,139,and 48 Japanese obese children at 7,10,and 13 years of age, respectively. Polymorphism in the β3AR gene was analyzed using a polymerase chain reaction and the restriction enzyme of BstNI as well as serum levels of lipids and insulin in fasting blood samples. Analyses revealed seven Arg64 homozygotes, 101 Trp64/Arg64 heterozygotes, and 151 Trp64 homozygotes. Seven-year-old subjects with the mutation (n=27) had a larger relative weight (154.8±10.6%), higher ponderal index (kg/m^3) (19.0±1.3), and higher levels of triglyceride (95.6±46.0 mg/dl) and insulin (9.3±3.0μ U/ml) than those without the mutation (n=45) (149.3±8.9%, 18.3±1.1,74.8±31.4mg/dl, and 7.6±2.5μU/ml, respectively, p<0.05). In either 10 or 13-year-old, no significant differences were observed in the above mentioned parameters between subjects with or without the mutation. These results suggest that a polymorphism in the β3AR gene contributes to obesity and is associated with hyperinsulinemia and hypertriglyceridemia in younger obese children. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 48, 号 4, p. 135-139, 発行日 2000-12 |
|||||
出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
著者版フラグ | ||||||
値 | publisher |