{"created":"2021-03-01T06:10:13.170182+00:00","id":6319,"links":{},"metadata":{"_buckets":{"deposit":"03d10fdc-07f8-4eca-91fa-549dd6b53505"},"_deposit":{"id":"6319","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6319"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006319","sets":["453:456","471:537:568:601"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"139","bibliographicPageStart":"135","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Genetic factors of obesity that have recently been revealed include the β3-adrenergic receptor (β3AR) gene. The aim of this study is to examine the possible role in childhood obesity of a mutation in the β3AR gene. This study examined 72,139,and 48 Japanese obese children at 7,10,and 13 years of age, respectively. Polymorphism in the β3AR gene was analyzed using a polymerase chain reaction and the restriction enzyme of BstNI as well as serum levels of lipids and insulin in fasting blood samples. Analyses revealed seven Arg64 homozygotes, 101 Trp64/Arg64 heterozygotes, and 151 Trp64 homozygotes. Seven-year-old subjects with the mutation (n=27) had a larger relative weight (154.8±10.6%), higher ponderal index (kg/m^3) (19.0±1.3), and higher levels of triglyceride (95.6±46.0 mg/dl) and insulin (9.3±3.0μ U/ml) than those without the mutation (n=45) (149.3±8.9%, 18.3±1.1,74.8±31.4mg/dl, and 7.6±2.5μU/ml, respectively, p<0.05). In either 10 or 13-year-old, no significant differences were observed in the above mentioned parameters between subjects with or without the mutation. These results suggest that a polymorphism in the β3AR gene contributes to obesity and is associated with hyperinsulinemia and hypertriglyceridemia in younger obese children.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KIKUCHI, Toru"}],"nameIdentifiers":[{"nameIdentifier":"52326","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HASHIMOTO, Naoshi"}],"nameIdentifiers":[{"nameIdentifier":"52327","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAWASAKI, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"52328","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"OKUGAWA, Takayoshi"}],"nameIdentifiers":[{"nameIdentifier":"52329","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"UCHIYAMA, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"52330","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"KJ00000007274.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000007274.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6319/files/KJ00000007274.pdf"},"version_id":"8017d587-82f8-4b31-b9d8-8791b3676c52"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"lipid","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin","subitem_subject_scheme":"Other"},{"subitem_subject":"apolipoprotein","subitem_subject_scheme":"Other"},{"subitem_subject":"fat","subitem_subject_scheme":"Other"},{"subitem_subject":"polymerase chain reaction","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity"},{"subitem_title":"Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","601"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"6319","relation_version_is_last":true,"title":["Association Between a Polymorphism in the β3-adrenergic Receptor Gene and Childhood Obesity"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:38.401256+00:00"}