{"_buckets": {"deposit": "80d37971-ae05-4592-a84c-176e69c7d572"}, "_deposit": {"id": "6310", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6310"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006310", "sets": ["456", "600"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "4", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "49", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The effects of a chronic administration of a non-selective β-blocker, bopindolol, on the binding characteristics of radiolabeled CGP-12177 (^3H-CGP12177) to each β_1-and β_2-adrenoceptor subtype in the kidney of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) were determined using the radioligand binding assay method and compared with those of a β_1-selective β-blocker, atenolol. Bopindolol (1 mg/kg/day and 3 mg/kg/day) and atenolol (50 mg/kg/day) were given to 10-week-old SHR for 12 weeks. The changes in Kd and Bmax values of β_1-and β_2-adrenoceptors in the renal membranes of SHR treated both with and without these drugs were assessed by Scatchard analysis, and Bmax values and the ratios of β_1-and β_2-adrenoceptor subtypes were also calculated from displacement curves using ICI-118,551. Bmax values of β_1- and β_2-adrenoceptors in the renal membranes of SHR were significantly higher than those of WKY. The elevated Bmax values of β_1- and β_2-adrenoceptors in renal membranes of SHR were reduced by an administration of bopindolol (1 mg/kg/day and 3 mg/kg/day) with no changes in the Kd values, these changes being especially marked in β_2-adrenoceptors. No effects of the β_1-selective antagonist atenolol on these parameters were observed. These findings showed that the non-selective antagonist bopindolol decreased the Bmax values of β-adrenoceptor subtypes in renal membranes of SHR, suggesting that this drug may partially contribute to hypotensive effects.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "NAKAMURA, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "52272", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HOSOHATA, Yoshiaki"}], "nameIdentifiers": [{"nameIdentifier": "52273", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HATTORI, Kaoru"}], "nameIdentifiers": [{"nameIdentifier": "52274", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SUZUKI, Jun"}], "nameIdentifiers": [{"nameIdentifier": "52275", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAGATOMO, Takafumi"}], "nameIdentifiers": [{"nameIdentifier": "52276", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000007286.pdf", "filesize": [{"value": "2.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2800000.0, "url": {"label": "KJ00000007286.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6310/files/KJ00000007286.pdf"}, "version_id": "750b1252-570f-4409-95c1-902bfe638cfb"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "bopindolol", "subitem_subject_scheme": "Other"}, {"subitem_subject": "atenolol", "subitem_subject_scheme": "Other"}, {"subitem_subject": "β-blocker", "subitem_subject_scheme": "Other"}, {"subitem_subject": "β-adrenoceptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "spontaneously hypetensive rats (SHR)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "kindly", "subitem_subject_scheme": "Other"}, {"subitem_subject": "blood pressure", "subitem_subject_scheme": "Other"}, {"subitem_subject": "radioligand binding assay", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Different Effects of a Long-term Administration of β-blockers, Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of Spontaneously Hypertensive Rats (SHR)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Different Effects of a Long-term Administration of β-blockers, Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of Spontaneously Hypertensive Rats (SHR)"}, {"subitem_title": "Different Effects of a Long-term Administration of β-blockers, Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of Spontaneously Hypertensive Rats (SHR)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "600"], "permalink_uri": "http://hdl.handle.net/10191/1838", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6310", "relation": {}, "relation_version_is_last": true, "title": ["Different Effects of a Long-term Administration of β-blockers, Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of Spontaneously Hypertensive Rats (SHR)"], "weko_shared_id": null}