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Different Effects of a Long-term Administration of β-blockers, Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of Spontaneously Hypertensive Rats (SHR)
http://hdl.handle.net/10191/1838
http://hdl.handle.net/10191/1838a78c3692-6afe-452b-b7b2-a52715dd746d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000007286.pdf (2.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Different Effects of a Long-term Administration of β-blockers, Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of Spontaneously Hypertensive Rats (SHR) | |||||
| タイトル | ||||||
| タイトル | Different Effects of a Long-term Administration of β-blockers, Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of Spontaneously Hypertensive Rats (SHR) | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bopindolol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | atenolol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | β-blocker | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | β-adrenoceptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | spontaneously hypetensive rats (SHR) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | kindly | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | blood pressure | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | radioligand binding assay | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
NAKAMURA, Takashi
× NAKAMURA, Takashi× HOSOHATA, Yoshiaki× HATTORI, Kaoru× SUZUKI, Jun× NAGATOMO, Takafumi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The effects of a chronic administration of a non-selective β-blocker, bopindolol, on the binding characteristics of radiolabeled CGP-12177 (^3H-CGP12177) to each β_1-and β_2-adrenoceptor subtype in the kidney of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) were determined using the radioligand binding assay method and compared with those of a β_1-selective β-blocker, atenolol. Bopindolol (1 mg/kg/day and 3 mg/kg/day) and atenolol (50 mg/kg/day) were given to 10-week-old SHR for 12 weeks. The changes in Kd and Bmax values of β_1-and β_2-adrenoceptors in the renal membranes of SHR treated both with and without these drugs were assessed by Scatchard analysis, and Bmax values and the ratios of β_1-and β_2-adrenoceptor subtypes were also calculated from displacement curves using ICI-118,551. Bmax values of β_1- and β_2-adrenoceptors in the renal membranes of SHR were significantly higher than those of WKY. The elevated Bmax values of β_1- and β_2-adrenoceptors in renal membranes of SHR were reduced by an administration of bopindolol (1 mg/kg/day and 3 mg/kg/day) with no changes in the Kd values, these changes being especially marked in β_2-adrenoceptors. No effects of the β_1-selective antagonist atenolol on these parameters were observed. These findings showed that the non-selective antagonist bopindolol decreased the Bmax values of β-adrenoceptor subtypes in renal membranes of SHR, suggesting that this drug may partially contribute to hypotensive effects. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 49, 号 1, p. 1-4, 発行日 2001-03 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
