{"created":"2021-03-01T06:10:12.607532+00:00","id":6310,"links":{},"metadata":{"_buckets":{"deposit":"80d37971-ae05-4592-a84c-176e69c7d572"},"_deposit":{"id":"6310","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6310"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006310","sets":["453:456","471:537:568:600"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effects of a chronic administration of a non-selective β-blocker, bopindolol, on the binding characteristics of radiolabeled CGP-12177 (^3H-CGP12177) to each β_1-and β_2-adrenoceptor subtype in the kidney of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) were determined using the radioligand binding assay method and compared with those of a β_1-selective β-blocker, atenolol. Bopindolol (1 mg/kg/day and 3 mg/kg/day) and atenolol (50 mg/kg/day) were given to 10-week-old SHR for 12 weeks. The changes in Kd and Bmax values of β_1-and β_2-adrenoceptors in the renal membranes of SHR treated both with and without these drugs were assessed by Scatchard analysis, and Bmax values and the ratios of β_1-and β_2-adrenoceptor subtypes were also calculated from displacement curves using ICI-118,551. Bmax values of β_1- and β_2-adrenoceptors in the renal membranes of SHR were significantly higher than those of WKY. The elevated Bmax values of β_1- and β_2-adrenoceptors in renal membranes of SHR were reduced by an administration of bopindolol (1 mg/kg/day and 3 mg/kg/day) with no changes in the Kd values, these changes being especially marked in β_2-adrenoceptors. No effects of the β_1-selective antagonist atenolol on these parameters were observed. These findings showed that the non-selective antagonist bopindolol decreased the Bmax values of β-adrenoceptor subtypes in renal membranes of SHR, suggesting that this drug may partially contribute to hypotensive effects.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NAKAMURA, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"52272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HOSOHATA, Yoshiaki"}],"nameIdentifiers":[{"nameIdentifier":"52273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HATTORI, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"52274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SUZUKI, Jun"}],"nameIdentifiers":[{"nameIdentifier":"52275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"NAGATOMO, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"52276","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"KJ00000007286.pdf","filesize":[{"value":"2.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00000007286.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6310/files/KJ00000007286.pdf"},"version_id":"750b1252-570f-4409-95c1-902bfe638cfb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"bopindolol","subitem_subject_scheme":"Other"},{"subitem_subject":"atenolol","subitem_subject_scheme":"Other"},{"subitem_subject":"β-blocker","subitem_subject_scheme":"Other"},{"subitem_subject":"β-adrenoceptor","subitem_subject_scheme":"Other"},{"subitem_subject":"spontaneously hypetensive rats (SHR)","subitem_subject_scheme":"Other"},{"subitem_subject":"kindly","subitem_subject_scheme":"Other"},{"subitem_subject":"blood pressure","subitem_subject_scheme":"Other"},{"subitem_subject":"radioligand binding assay","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Different Effects of a Long-term Administration of β-blockers, Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of Spontaneously Hypertensive Rats (SHR)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Different Effects of a Long-term Administration of β-blockers, Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of Spontaneously Hypertensive Rats (SHR)"},{"subitem_title":"Different Effects of a Long-term Administration of β-blockers, Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of Spontaneously Hypertensive Rats (SHR)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","600"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"6310","relation_version_is_last":true,"title":["Different Effects of a Long-term Administration of β-blockers, Bopindolol and Atenolol, on the Binding Characteristics ofβ_1-and β_2-adrenoceptor Subtypes in the Kidney of Spontaneously Hypertensive Rats (SHR)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:38.648345+00:00"}