{"_buckets": {"deposit": "6c021bfa-5778-4517-a493-619faf891259"}, "_deposit": {"id": "6302", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6302"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006302"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3-4", "bibliographicPageEnd": "80", "bibliographicPageStart": "73", "bibliographicVolumeNumber": "49", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "We compared the acute phase responses of mesangial cells and inflammatory cells in reversible and irreversible mesangial alterations. We used a reversible model that induced by a single injection of anti-Thy 1.1 monoclonal antibody (mAb) 1-22-3,and an irreversible model of glomerulonephritis induced by two consecutive injections of mAb 1-22-3 with an interval of 2 weeks. Similar mesangiolysis occurred in both models. However, pathological phenotypic changes in the mesangial cell began more rapidly and markedly after the second wave of mesangiolysis. Glomerular mRNA expression of platelet-derived growth factor (PDGF) was higher in the irreversible model than in the reversible model, whereas mRNA expression of monocyte chemoattractant protein-1 (MCP-1) was lower in the irreversible model. The numbers of polymorphonuclear cell (PMN) and ED1^+ monocytes/macrophages were lower in the irreversible model than in the reversible model. By contrast, the recruitment of ED3^+ cells into the glomeruli was dominant in the irreversible model. A dual labeling study showed that major parts of ED3^+ cells in the glomeruli of the irreversible model were ED1 negative. ED3^+ ED1^- cells were not detected at any time in the reversible model. The ED3^+ cell should be regarded as an important candidate for acting on the mesangial cell to lead to irreversible mesangial alterations.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "ITO, Yumi"}], "nameIdentifiers": [{"nameIdentifier": "52230", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MORIOKA, Yoshio"}], "nameIdentifiers": [{"nameIdentifier": "52231", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOIKE, Hiroko"}], "nameIdentifiers": [{"nameIdentifier": "52232", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IKEZUMI, Yohei"}], "nameIdentifiers": [{"nameIdentifier": "52233", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOBAYASHI, Hideo"}], "nameIdentifiers": [{"nameIdentifier": "52234", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "GEJYO, Fumitake"}], "nameIdentifiers": [{"nameIdentifier": "52235", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SHIMIZU, Fujio"}], "nameIdentifiers": [{"nameIdentifier": "52236", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAWACHI, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "52237", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00001015037.pdf", "filesize": [{"value": "3.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3100000.0, "url": {"label": "KJ00001015037.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6302/files/KJ00001015037.pdf"}, "version_id": "696fafdf-e4a1-4a1d-acf5-e805a2ce56b4"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Thy 1.1. nephritis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mAb 1-22-3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ED3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MCP-1", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes"}, {"subitem_title": "Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/598"], "permalink_uri": "http://hdl.handle.net/10191/1895", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6302", "relation": {}, "relation_version_is_last": true, "title": ["Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes"], "weko_shared_id": null}