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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.49 No.3,4

Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes

http://hdl.handle.net/10191/1895
http://hdl.handle.net/10191/1895
f5e0a9c2-f6e0-40c3-bf69-3bc7e15392b2
名前 / ファイル ライセンス アクション
KJ00001015037.pdf KJ00001015037.pdf (3.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes
タイトル
言語 en
タイトル Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes
言語
言語 eng
キーワード
主題Scheme Other
主題 Thy 1.1. nephritis
キーワード
主題Scheme Other
主題 mAb 1-22-3
キーワード
主題Scheme Other
主題 ED3
キーワード
主題Scheme Other
主題 MCP-1
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 ITO, Yumi

× ITO, Yumi

WEKO 52230

ITO, Yumi

Search repository
MORIOKA, Yoshio

× MORIOKA, Yoshio

WEKO 52231

MORIOKA, Yoshio

Search repository
KOIKE, Hiroko

× KOIKE, Hiroko

WEKO 52232

KOIKE, Hiroko

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IKEZUMI, Yohei

× IKEZUMI, Yohei

WEKO 52233

IKEZUMI, Yohei

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KOBAYASHI, Hideo

× KOBAYASHI, Hideo

WEKO 52234

KOBAYASHI, Hideo

Search repository
GEJYO, Fumitake

× GEJYO, Fumitake

WEKO 52235

GEJYO, Fumitake

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SHIMIZU, Fujio

× SHIMIZU, Fujio

WEKO 52236

SHIMIZU, Fujio

Search repository
KAWACHI, Hiroshi

× KAWACHI, Hiroshi

WEKO 52237

KAWACHI, Hiroshi

Search repository
抄録
内容記述タイプ Abstract
内容記述 We compared the acute phase responses of mesangial cells and inflammatory cells in reversible and irreversible mesangial alterations. We used a reversible model that induced by a single injection of anti-Thy 1.1 monoclonal antibody (mAb) 1-22-3,and an irreversible model of glomerulonephritis induced by two consecutive injections of mAb 1-22-3 with an interval of 2 weeks. Similar mesangiolysis occurred in both models. However, pathological phenotypic changes in the mesangial cell began more rapidly and markedly after the second wave of mesangiolysis. Glomerular mRNA expression of platelet-derived growth factor (PDGF) was higher in the irreversible model than in the reversible model, whereas mRNA expression of monocyte chemoattractant protein-1 (MCP-1) was lower in the irreversible model. The numbers of polymorphonuclear cell (PMN) and ED1^+ monocytes/macrophages were lower in the irreversible model than in the reversible model. By contrast, the recruitment of ED3^+ cells into the glomeruli was dominant in the irreversible model. A dual labeling study showed that major parts of ED3^+ cells in the glomeruli of the irreversible model were ED1 negative. ED3^+ ED1^- cells were not detected at any time in the reversible model. The ED3^+ cell should be regarded as an important candidate for acting on the mesangial cell to lead to irreversible mesangial alterations.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 49, 号 3-4, p. 73-80, 発行日 2001-09
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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