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Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes
http://hdl.handle.net/10191/1895
http://hdl.handle.net/10191/1895f5e0a9c2-f6e0-40c3-bf69-3bc7e15392b2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00001015037.pdf (3.1 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes | |||||
| タイトル | ||||||
| タイトル | Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Thy 1.1. nephritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mAb 1-22-3 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ED3 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MCP-1 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
ITO, Yumi
× ITO, Yumi× MORIOKA, Yoshio× KOIKE, Hiroko× IKEZUMI, Yohei× KOBAYASHI, Hideo× GEJYO, Fumitake× SHIMIZU, Fujio× KAWACHI, Hiroshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We compared the acute phase responses of mesangial cells and inflammatory cells in reversible and irreversible mesangial alterations. We used a reversible model that induced by a single injection of anti-Thy 1.1 monoclonal antibody (mAb) 1-22-3,and an irreversible model of glomerulonephritis induced by two consecutive injections of mAb 1-22-3 with an interval of 2 weeks. Similar mesangiolysis occurred in both models. However, pathological phenotypic changes in the mesangial cell began more rapidly and markedly after the second wave of mesangiolysis. Glomerular mRNA expression of platelet-derived growth factor (PDGF) was higher in the irreversible model than in the reversible model, whereas mRNA expression of monocyte chemoattractant protein-1 (MCP-1) was lower in the irreversible model. The numbers of polymorphonuclear cell (PMN) and ED1^+ monocytes/macrophages were lower in the irreversible model than in the reversible model. By contrast, the recruitment of ED3^+ cells into the glomeruli was dominant in the irreversible model. A dual labeling study showed that major parts of ED3^+ cells in the glomeruli of the irreversible model were ED1 negative. ED3^+ ED1^- cells were not detected at any time in the reversible model. The ED3^+ cell should be regarded as an important candidate for acting on the mesangial cell to lead to irreversible mesangial alterations. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 49, 号 3-4, p. 73-80, 発行日 2001-09 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
