{"created":"2021-03-01T06:10:12.107856+00:00","id":6302,"links":{},"metadata":{"_buckets":{"deposit":"6c021bfa-5778-4517-a493-619faf891259"},"_deposit":{"id":"6302","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6302"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006302","sets":["453:456","471:537:568:598"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"80","bibliographicPageStart":"73","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We compared the acute phase responses of mesangial cells and inflammatory cells in reversible and irreversible mesangial alterations. We used a reversible model that induced by a single injection of anti-Thy 1.1 monoclonal antibody (mAb) 1-22-3,and an irreversible model of glomerulonephritis induced by two consecutive injections of mAb 1-22-3 with an interval of 2 weeks. Similar mesangiolysis occurred in both models. However, pathological phenotypic changes in the mesangial cell began more rapidly and markedly after the second wave of mesangiolysis. Glomerular mRNA expression of platelet-derived growth factor (PDGF) was higher in the irreversible model than in the reversible model, whereas mRNA expression of monocyte chemoattractant protein-1 (MCP-1) was lower in the irreversible model. The numbers of polymorphonuclear cell (PMN) and ED1^+ monocytes/macrophages were lower in the irreversible model than in the reversible model. By contrast, the recruitment of ED3^+ cells into the glomeruli was dominant in the irreversible model. A dual labeling study showed that major parts of ED3^+ cells in the glomeruli of the irreversible model were ED1 negative. ED3^+ ED1^- cells were not detected at any time in the reversible model. The ED3^+ cell should be regarded as an important candidate for acting on the mesangial cell to lead to irreversible mesangial alterations.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ITO, Yumi"}],"nameIdentifiers":[{"nameIdentifier":"52230","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MORIOKA, Yoshio"}],"nameIdentifiers":[{"nameIdentifier":"52231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KOIKE, Hiroko"}],"nameIdentifiers":[{"nameIdentifier":"52232","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IKEZUMI, Yohei"}],"nameIdentifiers":[{"nameIdentifier":"52233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KOBAYASHI, Hideo"}],"nameIdentifiers":[{"nameIdentifier":"52234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"GEJYO, Fumitake"}],"nameIdentifiers":[{"nameIdentifier":"52235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SHIMIZU, Fujio"}],"nameIdentifiers":[{"nameIdentifier":"52236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAWACHI, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"52237","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"KJ00001015037.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00001015037.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6302/files/KJ00001015037.pdf"},"version_id":"696fafdf-e4a1-4a1d-acf5-e805a2ce56b4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Thy 1.1. nephritis","subitem_subject_scheme":"Other"},{"subitem_subject":"mAb 1-22-3","subitem_subject_scheme":"Other"},{"subitem_subject":"ED3","subitem_subject_scheme":"Other"},{"subitem_subject":"MCP-1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes"},{"subitem_title":"Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","598"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"6302","relation_version_is_last":true,"title":["Not the ED1^+ but the ED3^+ Macrophage Participates in the Pathogenesis of Irreversible Glomerular Changes"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:37.431444+00:00"}