{"_buckets": {"deposit": "d76621de-56d6-4046-894f-20fb7f5fa6b5"}, "_deposit": {"id": "6245", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6245"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006245"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "110", "bibliographicPageStart": "103", "bibliographicVolumeNumber": "52", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The distribution of neuropeptide Y (NPY) correlates well with that of the T-type Ca^\u003c2+\u003e channel in the central and peripheral nervous systems, suggesting a functional interaction between them. Here, we report that NPY significantly augmented the T-type Ca^\u003c2+\u003e channel current expressed in undifferentiated NG108-15 cells using Ba^\u003c2+\u003e as the charge carrier. Although the extent of augmentation was small (9.8%), the NPY treatment shifted the I-V relationship negatively. L-152, 804, a NPY-Y_5 receptor-selective antagonist, had no effect on the augmentation, whereas BIBP3226, a Y_1 receptor-selective antagonist, significantly suppressed the augmentation to 39.4%. Likewise, NPY (13-36), a Y_2-selective agonist, had a partial (43.7%) but significant augmentative effect on the T-type Ba^\u003c2+\u003e current. Consistently, RT-PCR analysis confirmed the expressions of mRNAs for Y_1 and Y_2 receptors but not that for Y_5 receptor, suggesting an additive contribution of the subtypes. Thus, NPY may play a role in regulating excitability via the augmentation of the T-type Ca^\u003c2+\u003e channel current.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "OKADA, Masayoshi"}], "nameIdentifiers": [{"nameIdentifier": "51889", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HASEGAWA, Ayumi"}], "nameIdentifiers": [{"nameIdentifier": "51890", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HIGUCHI, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "51891", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004267794.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "KJ00004267794.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6245/files/KJ00004267794.pdf"}, "version_id": "12ace234-1071-48c7-a5b0-40d330560baf"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "T-type Ca^\u003c2+\u003e channel", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Neuropeptide Y", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NG108-15 cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Y_1 and Y_2 receptors", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effect of Neuropeptide Y on the T-type Ca^\u003c2+\u003e Channel Current Expressed in NG108-15 Cells", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Effect of Neuropeptide Y on the T-type Ca^\u003c2+\u003e Channel Current Expressed in NG108-15 Cells"}, {"subitem_title": "Effect of Neuropeptide Y on the T-type Ca^\u003c2+\u003e Channel Current Expressed in NG108-15 Cells", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/587"], "permalink_uri": "http://hdl.handle.net/10191/1871", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6245", "relation": {}, "relation_version_is_last": true, "title": ["Effect of Neuropeptide Y on the T-type Ca^\u003c2+\u003e Channel Current Expressed in NG108-15 Cells"], "weko_shared_id": null}