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Effect of Neuropeptide Y on the T-type Ca^<2+> Channel Current Expressed in NG108-15 Cells
http://hdl.handle.net/10191/1871
http://hdl.handle.net/10191/187131b8ed91-6a88-498f-87c4-5dd4a947deff
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-05-10 | |||||
タイトル | ||||||
タイトル | Effect of Neuropeptide Y on the T-type Ca^<2+> Channel Current Expressed in NG108-15 Cells | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of Neuropeptide Y on the T-type Ca^<2+> Channel Current Expressed in NG108-15 Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T-type Ca^<2+> channel | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neuropeptide Y | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NG108-15 cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Y_1 and Y_2 receptors | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
OKADA, Masayoshi
× OKADA, Masayoshi× HASEGAWA, Ayumi× HIGUCHI, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The distribution of neuropeptide Y (NPY) correlates well with that of the T-type Ca^<2+> channel in the central and peripheral nervous systems, suggesting a functional interaction between them. Here, we report that NPY significantly augmented the T-type Ca^<2+> channel current expressed in undifferentiated NG108-15 cells using Ba^<2+> as the charge carrier. Although the extent of augmentation was small (9.8%), the NPY treatment shifted the I-V relationship negatively. L-152, 804, a NPY-Y_5 receptor-selective antagonist, had no effect on the augmentation, whereas BIBP3226, a Y_1 receptor-selective antagonist, significantly suppressed the augmentation to 39.4%. Likewise, NPY (13-36), a Y_2-selective agonist, had a partial (43.7%) but significant augmentative effect on the T-type Ba^<2+> current. Consistently, RT-PCR analysis confirmed the expressions of mRNAs for Y_1 and Y_2 receptors but not that for Y_5 receptor, suggesting an additive contribution of the subtypes. Thus, NPY may play a role in regulating excitability via the augmentation of the T-type Ca^<2+> channel current. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 52, 号 3, p. 103-110, 発行日 2004-09 |
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出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
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収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
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値 | publisher |