{"created":"2021-03-01T06:10:08.469844+00:00","id":6245,"links":{},"metadata":{"_buckets":{"deposit":"d76621de-56d6-4046-894f-20fb7f5fa6b5"},"_deposit":{"id":"6245","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6245"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006245","sets":["453:456","471:537:568:587"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"110","bibliographicPageStart":"103","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The distribution of neuropeptide Y (NPY) correlates well with that of the T-type Ca^<2+> channel in the central and peripheral nervous systems, suggesting a functional interaction between them. Here, we report that NPY significantly augmented the T-type Ca^<2+> channel current expressed in undifferentiated NG108-15 cells using Ba^<2+> as the charge carrier. Although the extent of augmentation was small (9.8%), the NPY treatment shifted the I-V relationship negatively. L-152, 804, a NPY-Y_5 receptor-selective antagonist, had no effect on the augmentation, whereas BIBP3226, a Y_1 receptor-selective antagonist, significantly suppressed the augmentation to 39.4%. Likewise, NPY (13-36), a Y_2-selective agonist, had a partial (43.7%) but significant augmentative effect on the T-type Ba^<2+> current. Consistently, RT-PCR analysis confirmed the expressions of mRNAs for Y_1 and Y_2 receptors but not that for Y_5 receptor, suggesting an additive contribution of the subtypes. Thus, NPY may play a role in regulating excitability via the augmentation of the T-type Ca^<2+> channel current.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"OKADA, Masayoshi"}],"nameIdentifiers":[{"nameIdentifier":"51889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HASEGAWA, Ayumi"}],"nameIdentifiers":[{"nameIdentifier":"51890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HIGUCHI, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"51891","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"KJ00004267794.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004267794.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6245/files/KJ00004267794.pdf"},"version_id":"12ace234-1071-48c7-a5b0-40d330560baf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"T-type Ca^<2+> channel","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuropeptide Y","subitem_subject_scheme":"Other"},{"subitem_subject":"NG108-15 cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Y_1 and Y_2 receptors","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Neuropeptide Y on the T-type Ca^<2+> Channel Current Expressed in NG108-15 Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Neuropeptide Y on the T-type Ca^<2+> Channel Current Expressed in NG108-15 Cells"},{"subitem_title":"Effect of Neuropeptide Y on the T-type Ca^<2+> Channel Current Expressed in NG108-15 Cells","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","587"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"6245","relation_version_is_last":true,"title":["Effect of Neuropeptide Y on the T-type Ca^<2+> Channel Current Expressed in NG108-15 Cells"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:36.121309+00:00"}