{"_buckets": {"deposit": "a494a6dd-c2f6-4041-b1cb-cb55ae432590"}, "_deposit": {"id": "6242", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6242"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006242", "sets": ["456", "587"]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "89", "bibliographicPageStart": "81", "bibliographicVolumeNumber": "52", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "To evaluate the involvement between Fasassociated phosphatase-1 (FAP-1) and drug resistance, the expression of FAP-1 in leukemic cell lines, drugresistant sublines, and leukemic cells was examined by RT-PCR. In comparison with the parental cell line (KY-821), arabinofuranosylcytosine (ara-C)-resistant subline (KY-Ra), and vincristine (VCR)-resistant subline (KY-VCR) showed an increase in FAP-1 expression and resistance to anti-CD95 antibody-induced apoptosis. Leukemic cell lines (KY-821 and Jurkat) revealed an increase in FAP-1 expression after exposure to ara-C (1×10^\u003c-5\u003eM) and VCR (1×10^\u003c-7\u003eM). Furthermore, after exposure to anticancer drugs at low dosages for five days, both KY-821 and Jurkat revealed an increase in FAP-1 expression and resistance to anti-CD95 antibody-induced apoptosis. In study with de novo leukemic cells, two cases showed an increase in FAP-1 expression after exposure to anticancer drugs, of which one revealed an increased resistance to anti-CD95 antibody-induced apoptosis. These results indicate a close involvement between CD95-mediated apoptosis and drug resistance, and suggest that anticancer drugs suppress CD95-mediated apoptosis in part by inducing FAP-1 overexpression in some leukemic cells.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "IMAMURA, Masaru"}], "nameIdentifiers": [{"nameIdentifier": "51877", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAKIHARA, Toshio"}], "nameIdentifiers": [{"nameIdentifier": "51878", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOBAYASHI, Takehiro"}], "nameIdentifiers": [{"nameIdentifier": "51879", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IMAI, Chihaya"}], "nameIdentifiers": [{"nameIdentifier": "51880", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TANAKA, Atsushi"}], "nameIdentifiers": [{"nameIdentifier": "51881", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "UCHIYAMA, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "51882", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004267791.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "KJ00004267791.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6242/files/KJ00004267791.pdf"}, "version_id": "0b40fdf2-d319-4929-bf54-0f04b83b60a1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "apoptosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD95", "subitem_subject_scheme": "Other"}, {"subitem_subject": "drug resistance", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Fasassociated phosphatase-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "leukemia", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells"}, {"subitem_title": "Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "587"], "permalink_uri": "http://hdl.handle.net/10191/1841", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6242", "relation": {}, "relation_version_is_last": true, "title": ["Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells"], "weko_shared_id": null}