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Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells
http://hdl.handle.net/10191/1841
http://hdl.handle.net/10191/1841bee57c40-c1a3-41be-b864-599a7ad66e30
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004267791.pdf (1.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-10 | |||||
| タイトル | ||||||
| タイトル | Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells | |||||
| タイトル | ||||||
| タイトル | Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | apoptosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CD95 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | drug resistance | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fasassociated phosphatase-1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | leukemia | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
IMAMURA, Masaru
× IMAMURA, Masaru× KAKIHARA, Toshio× KOBAYASHI, Takehiro× IMAI, Chihaya× TANAKA, Atsushi× UCHIYAMA, Makoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To evaluate the involvement between Fasassociated phosphatase-1 (FAP-1) and drug resistance, the expression of FAP-1 in leukemic cell lines, drugresistant sublines, and leukemic cells was examined by RT-PCR. In comparison with the parental cell line (KY-821), arabinofuranosylcytosine (ara-C)-resistant subline (KY-Ra), and vincristine (VCR)-resistant subline (KY-VCR) showed an increase in FAP-1 expression and resistance to anti-CD95 antibody-induced apoptosis. Leukemic cell lines (KY-821 and Jurkat) revealed an increase in FAP-1 expression after exposure to ara-C (1×10^<-5>M) and VCR (1×10^<-7>M). Furthermore, after exposure to anticancer drugs at low dosages for five days, both KY-821 and Jurkat revealed an increase in FAP-1 expression and resistance to anti-CD95 antibody-induced apoptosis. In study with de novo leukemic cells, two cases showed an increase in FAP-1 expression after exposure to anticancer drugs, of which one revealed an increased resistance to anti-CD95 antibody-induced apoptosis. These results indicate a close involvement between CD95-mediated apoptosis and drug resistance, and suggest that anticancer drugs suppress CD95-mediated apoptosis in part by inducing FAP-1 overexpression in some leukemic cells. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 52, 号 3, p. 81-89, 発行日 2004-09 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
IMAMURA, Masaru, KAKIHARA, Toshio, KOBAYASHI, Takehiro, IMAI, Chihaya, TANAKA, Atsushi, UCHIYAMA, Makoto, 2004, Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells: Niigata University School of Medicine, 81–89 p.
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