{"created":"2021-03-01T06:10:08.274210+00:00","id":6242,"links":{},"metadata":{"_buckets":{"deposit":"a494a6dd-c2f6-4041-b1cb-cb55ae432590"},"_deposit":{"id":"6242","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6242"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006242","sets":["453:456","471:537:568:587"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"89","bibliographicPageStart":"81","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To evaluate the involvement between Fasassociated phosphatase-1 (FAP-1) and drug resistance, the expression of FAP-1 in leukemic cell lines, drugresistant sublines, and leukemic cells was examined by RT-PCR. In comparison with the parental cell line (KY-821), arabinofuranosylcytosine (ara-C)-resistant subline (KY-Ra), and vincristine (VCR)-resistant subline (KY-VCR) showed an increase in FAP-1 expression and resistance to anti-CD95 antibody-induced apoptosis. Leukemic cell lines (KY-821 and Jurkat) revealed an increase in FAP-1 expression after exposure to ara-C (1×10^<-5>M) and VCR (1×10^<-7>M). Furthermore, after exposure to anticancer drugs at low dosages for five days, both KY-821 and Jurkat revealed an increase in FAP-1 expression and resistance to anti-CD95 antibody-induced apoptosis. In study with de novo leukemic cells, two cases showed an increase in FAP-1 expression after exposure to anticancer drugs, of which one revealed an increased resistance to anti-CD95 antibody-induced apoptosis. These results indicate a close involvement between CD95-mediated apoptosis and drug resistance, and suggest that anticancer drugs suppress CD95-mediated apoptosis in part by inducing FAP-1 overexpression in some leukemic cells.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IMAMURA, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"51877","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KAKIHARA, Toshio"}],"nameIdentifiers":[{"nameIdentifier":"51878","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KOBAYASHI, Takehiro"}],"nameIdentifiers":[{"nameIdentifier":"51879","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"IMAI, Chihaya"}],"nameIdentifiers":[{"nameIdentifier":"51880","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TANAKA, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"51881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"UCHIYAMA, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"51882","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"KJ00004267791.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004267791.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6242/files/KJ00004267791.pdf"},"version_id":"0b40fdf2-d319-4929-bf54-0f04b83b60a1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"CD95","subitem_subject_scheme":"Other"},{"subitem_subject":"drug resistance","subitem_subject_scheme":"Other"},{"subitem_subject":"Fasassociated phosphatase-1","subitem_subject_scheme":"Other"},{"subitem_subject":"leukemia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells"},{"subitem_title":"Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","587"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"6242","relation_version_is_last":true,"title":["Anticancer Drugs Overexpress Fas-associated Phosphatase-1 in Some Leukemic Cells"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:36.062637+00:00"}