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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.52 No.4

The Absence of a Significant Role for β-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma

http://hdl.handle.net/10191/1956
http://hdl.handle.net/10191/1956
840cbece-e313-4dc9-854b-caf6d817bcde
名前 / ファイル ライセンス アクション
KJ00004161687.pdf KJ00004161687.pdf (2.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2007-05-10
タイトル
タイトル The Absence of a Significant Role for β-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma
タイトル
言語 en
タイトル The Absence of a Significant Role for β-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma
言語
言語 eng
キーワード
主題Scheme Other
主題 serrated adenoma
キーワード
主題Scheme Other
主題 β-catenin
キーワード
主題Scheme Other
主題 tumorigenesis of colorectal adenoma
キーワード
主題Scheme Other
主題 immunohistochemistry
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Baba, Youichiro

× Baba, Youichiro

WEKO 51854

Baba, Youichiro

Search repository
Ajioka, Yoichi

× Ajioka, Yoichi

WEKO 51855

Ajioka, Yoichi

Search repository
Hirono, Haruka

× Hirono, Haruka

WEKO 51856

Hirono, Haruka

Search repository
Watanabe, Gen

× Watanabe, Gen

WEKO 51857

Watanabe, Gen

Search repository
Nishikura, Ken

× Nishikura, Ken

WEKO 51858

Nishikura, Ken

Search repository
Watanabe, Hidenobu

× Watanabe, Hidenobu

WEKO 51859

Watanabe, Hidenobu

Search repository
抄録
内容記述タイプ Abstract
内容記述 The nuclear accumulation of β-catenin due to adenomatous polyposis coli (APC) gene alterations plays a central role in the tumorigenesis of the traditional tubular adenoma (TA) through activation of the Wingless/Wnt signal transduction pathway. To determine whether β-catenin plays a role in the tumorigenesis of the serrated adenoma (SA), a newly proposed subtype of colorectal adenoma, we immunohistochemically evaluated the nuclear expression of β-catenin in SA compared with that of the traditional TA. Twenty-three samples of SA without familial adenomatous polyposis (FAP) and 24 samples of TA without FAP and TA with FAP were respectively examined. While nuclear β-catenin expression was demonstrated in 79% (19/24) of TAs without FAP and 91% (22/24) of TAs with FAP, that in SAs was 0% (0/23). The difference in the expression rate in TAs without and with FAP from that in SAs was significant (p<0.0001, respectively). These results indicate that the tumorigenesis of the SA is distinct from that of the traditional TA and that the SA does not follow a APC/β-catenin/ Wnt signaling pathway.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 52, 号 4, p. 127-132, 発行日 2004-12
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
著者版フラグ
値 publisher
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