{"_buckets": {"deposit": "5c9eece0-9c77-4a6b-bf02-17f635efe484"}, "_deposit": {"id": "6238", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6238"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006238"}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "132", "bibliographicPageStart": "127", "bibliographicVolumeNumber": "52", "bibliographic_titles": [{"bibliographic_title": "Acta medica et biologica"}, {"bibliographic_title": "Acta medica et biologica", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The nuclear accumulation of \u03b2-catenin due to adenomatous polyposis coli (APC) gene alterations plays a central role in the tumorigenesis of the traditional tubular adenoma (TA) through activation of the Wingless/Wnt signal transduction pathway. To determine whether \u03b2-catenin plays a role in the tumorigenesis of the serrated adenoma (SA), a newly proposed subtype of colorectal adenoma, we immunohistochemically evaluated the nuclear expression of \u03b2-catenin in SA compared with that of the traditional TA. Twenty-three samples of SA without familial adenomatous polyposis (FAP) and 24 samples of TA without FAP and TA with FAP were respectively examined. While nuclear \u03b2-catenin expression was demonstrated in 79% (19/24) of TAs without FAP and 91% (22/24) of TAs with FAP, that in SAs was 0% (0/23). The difference in the expression rate in TAs without and with FAP from that in SAs was significant (p\u003c0.0001, respectively). These results indicate that the tumorigenesis of the SA is distinct from that of the traditional TA and that the SA does not follow a APC/\u03b2-catenin/ Wnt signaling pathway.", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Niigata University School of Medicine"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00508361", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "05677734", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Baba, Youichiro"}], "nameIdentifiers": [{"nameIdentifier": "51854", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ajioka, Yoichi"}], "nameIdentifiers": [{"nameIdentifier": "51855", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirono, Haruka"}], "nameIdentifiers": [{"nameIdentifier": "51856", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Gen"}], "nameIdentifiers": [{"nameIdentifier": "51857", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishikura, Ken"}], "nameIdentifiers": [{"nameIdentifier": "51858", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Hidenobu"}], "nameIdentifiers": [{"nameIdentifier": "51859", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-06"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004161687.pdf", "filesize": [{"value": "2.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2600000.0, "url": {"label": "KJ00004161687.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/6238/files/KJ00004161687.pdf"}, "version_id": "c770dcdd-7ebe-47f6-ac2f-ffdb1d2007a3"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "serrated adenoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u03b2-catenin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tumorigenesis of colorectal adenoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immunohistochemistry", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Absence of a Significant Role for \u03b2-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "The Absence of a Significant Role for \u03b2-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma"}, {"subitem_title": "The Absence of a Significant Role for \u03b2-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/568/586"], "permalink_uri": "http://hdl.handle.net/10191/1956", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2007-05-10"}, "publish_date": "2007-05-10", "publish_status": "0", "recid": "6238", "relation": {}, "relation_version_is_last": true, "title": ["The Absence of a Significant Role for \u03b2-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma"], "weko_shared_id": null}