{"created":"2021-03-01T06:10:08.015185+00:00","id":6238,"links":{},"metadata":{"_buckets":{"deposit":"5c9eece0-9c77-4a6b-bf02-17f635efe484"},"_deposit":{"id":"6238","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6238"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006238","sets":["453:456","471:537:568:586"]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"132","bibliographicPageStart":"127","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Acta medica et biologica"},{"bibliographic_title":"Acta medica et biologica","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The nuclear accumulation of β-catenin due to adenomatous polyposis coli (APC) gene alterations plays a central role in the tumorigenesis of the traditional tubular adenoma (TA) through activation of the Wingless/Wnt signal transduction pathway. To determine whether β-catenin plays a role in the tumorigenesis of the serrated adenoma (SA), a newly proposed subtype of colorectal adenoma, we immunohistochemically evaluated the nuclear expression of β-catenin in SA compared with that of the traditional TA. Twenty-three samples of SA without familial adenomatous polyposis (FAP) and 24 samples of TA without FAP and TA with FAP were respectively examined. While nuclear β-catenin expression was demonstrated in 79% (19/24) of TAs without FAP and 91% (22/24) of TAs with FAP, that in SAs was 0% (0/23). The difference in the expression rate in TAs without and with FAP from that in SAs was significant (p<0.0001, respectively). These results indicate that the tumorigenesis of the SA is distinct from that of the traditional TA and that the SA does not follow a APC/β-catenin/ Wnt signaling pathway.","subitem_description_type":"Abstract"}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Niigata University School of Medicine"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00508361","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"05677734","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Baba, Youichiro"}],"nameIdentifiers":[{"nameIdentifier":"51854","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ajioka, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"51855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirono, Haruka"}],"nameIdentifiers":[{"nameIdentifier":"51856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Gen"}],"nameIdentifiers":[{"nameIdentifier":"51857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishikura, Ken"}],"nameIdentifiers":[{"nameIdentifier":"51858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Hidenobu"}],"nameIdentifiers":[{"nameIdentifier":"51859","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-06"}],"displaytype":"detail","filename":"KJ00004161687.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004161687.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/6238/files/KJ00004161687.pdf"},"version_id":"c770dcdd-7ebe-47f6-ac2f-ffdb1d2007a3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"serrated adenoma","subitem_subject_scheme":"Other"},{"subitem_subject":"β-catenin","subitem_subject_scheme":"Other"},{"subitem_subject":"tumorigenesis of colorectal adenoma","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Absence of a Significant Role for β-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Absence of a Significant Role for β-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma"},{"subitem_title":"The Absence of a Significant Role for β-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","586"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-10"},"publish_date":"2007-05-10","publish_status":"0","recid":"6238","relation_version_is_last":true,"title":["The Absence of a Significant Role for β-Catenin in the Tumorigenesis of the Serrated Adenoma of the Colorectum : A Comparative Study with the Traditional Tubular Colorectal Adenoma"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:39:36.034050+00:00"}