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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 01 Acta medica et biologica
  4. Vol.54 No.3

mRNA Expression of Vascular Endothelial Growth Factor-C and -D in Esophageal Squamous Cell Carcinoma

http://hdl.handle.net/10191/19588
http://hdl.handle.net/10191/19588
2ddffc42-062e-41d3-99ee-5ffa1925c34d
名前 / ファイル ライセンス アクション
110006483824.pdf 110006483824.pdf (746.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2012-09-28
タイトル
タイトル mRNA Expression of Vascular Endothelial Growth Factor-C and -D in Esophageal Squamous Cell Carcinoma
タイトル
タイトル mRNA Expression of Vascular Endothelial Growth Factor-C and -D in Esophageal Squamous Cell Carcinoma
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 VEGF-C
キーワード
主題Scheme Other
主題 VEGF-D
キーワード
主題Scheme Other
主題 mRNA
キーワード
主題Scheme Other
主題 esophageal carcinoma
キーワード
主題Scheme Other
主題 RT-PCR
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
著者 Kaneko, Kouji

× Kaneko, Kouji

WEKO 51666

Kaneko, Kouji

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Koyama, Yu

× Koyama, Yu

WEKO 51667

Koyama, Yu

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Kanda, Tatsuo

× Kanda, Tatsuo

WEKO 51668

Kanda, Tatsuo

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Honma, Hideyuki

× Honma, Hideyuki

WEKO 51669

Honma, Hideyuki

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Ohashi, Manabu

× Ohashi, Manabu

WEKO 51670

Ohashi, Manabu

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Nakagawa, Satoru

× Nakagawa, Satoru

WEKO 51671

Nakagawa, Satoru

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Hatakeyama, Katsuyoshi

× Hatakeyama, Katsuyoshi

WEKO 51672

Hatakeyama, Katsuyoshi

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抄録
内容記述タイプ Abstract
内容記述 Lymph node metastasis is a major prognostic factor for esophageal cancer patients. However, the molecular mechanisms underlying node metastasis remain unclear. Vascular endothelial growth factor-C (VEGF-C) and vascular endothelial growth factor-D (VEGF-D), which are ligands for VEGFR-3, have been reported to be capable of stimulating lymphangiogenesis under in vivo experimental conditions. The aim of the present study was to measure VEGF-C and/or VEGF-D mRNA expression in clinical specimens of esophageal squamous cell carcinoma, and to examine the correlation between VEGF-C or VEGF-D messenger ribonucleic acid (mRNA) expression and conventional clinicopathological parameters, especially the lymphatic involvement of esophageal squamous cell carcinoma. As a previous study has demonstrated that an expression pattern of high VEGF-C and low VEGF-D is correlated with both lymph node metastasis and lymphatic invasion of cancer cells, we also investigated the VEGF-C/D ratio. Total RNAs were isolated from 51 surgical specimens of esophageal carcinoma tissue and 42 normal esophageal mucosae. The relative mRNA abundance of VEGF-C and VEGF-D was measured by real-time quantitative reverse transcription polymerase chain reaction (PCR) analysis, and mRNA expression of VEGF-C and VEGF-D was standardized against glceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA expression. VEGF-C mRNA was expressed similarly in esophageal carcinoma tissue and normal mucosal tissue ; however, VEGF-D mRNA expression was significantly lower in carcinoma tissue compared with normal mucosal tissue, and therefore the VEGF-C/VEGF-D ratio was significantly increased in tumors compared with normal mucosae. However, neither mRNA expression of VEGF-C or VEGF-D nor the VEGF-C/VEGF-D ratio correlated with any clinicopathological factors, including lymphatic invasion, venous invasion, lymph node status, and tumor stage. VEGF-C and VEGF-D gene expression do not appear to be involved in the lymphatic progression of esophageal carcinoma.
書誌情報 Acta medica et biologica
en : Acta medica et biologica

巻 54, 号 3, p. 67-75, 発行日 2006-09
出版者
出版者 Niigata University School of Medicine
ISSN
収録物識別子タイプ ISSN
収録物識別子 05677734
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00508361
権利
権利情報 本文データは学協会の許諾に基づきCiNiiから複製したものである
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Cite as

Kaneko, Kouji, Koyama, Yu, Kanda, Tatsuo, Honma, Hideyuki, Ohashi, Manabu, Nakagawa, Satoru, Hatakeyama, Katsuyoshi, 2006, mRNA Expression of Vascular Endothelial Growth Factor-C and -D in Esophageal Squamous Cell Carcinoma: Niigata University School of Medicine, 67–75 p.

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