WEKO3
-
RootNode
アイテム
mRNA Expression of Vascular Endothelial Growth Factor-C and -D in Esophageal Squamous Cell Carcinoma
http://hdl.handle.net/10191/19588
http://hdl.handle.net/10191/195882ddffc42-062e-41d3-99ee-5ffa1925c34d
名前 / ファイル | ライセンス | アクション |
---|---|---|
![]() |
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2012-09-28 | |||||
タイトル | ||||||
タイトル | mRNA Expression of Vascular Endothelial Growth Factor-C and -D in Esophageal Squamous Cell Carcinoma | |||||
タイトル | ||||||
タイトル | mRNA Expression of Vascular Endothelial Growth Factor-C and -D in Esophageal Squamous Cell Carcinoma | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VEGF-C | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | VEGF-D | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mRNA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | esophageal carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RT-PCR | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
著者 |
Kaneko, Kouji
× Kaneko, Kouji× Koyama, Yu× Kanda, Tatsuo× Honma, Hideyuki× Ohashi, Manabu× Nakagawa, Satoru× Hatakeyama, Katsuyoshi |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Lymph node metastasis is a major prognostic factor for esophageal cancer patients. However, the molecular mechanisms underlying node metastasis remain unclear. Vascular endothelial growth factor-C (VEGF-C) and vascular endothelial growth factor-D (VEGF-D), which are ligands for VEGFR-3, have been reported to be capable of stimulating lymphangiogenesis under in vivo experimental conditions. The aim of the present study was to measure VEGF-C and/or VEGF-D mRNA expression in clinical specimens of esophageal squamous cell carcinoma, and to examine the correlation between VEGF-C or VEGF-D messenger ribonucleic acid (mRNA) expression and conventional clinicopathological parameters, especially the lymphatic involvement of esophageal squamous cell carcinoma. As a previous study has demonstrated that an expression pattern of high VEGF-C and low VEGF-D is correlated with both lymph node metastasis and lymphatic invasion of cancer cells, we also investigated the VEGF-C/D ratio. Total RNAs were isolated from 51 surgical specimens of esophageal carcinoma tissue and 42 normal esophageal mucosae. The relative mRNA abundance of VEGF-C and VEGF-D was measured by real-time quantitative reverse transcription polymerase chain reaction (PCR) analysis, and mRNA expression of VEGF-C and VEGF-D was standardized against glceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA expression. VEGF-C mRNA was expressed similarly in esophageal carcinoma tissue and normal mucosal tissue ; however, VEGF-D mRNA expression was significantly lower in carcinoma tissue compared with normal mucosal tissue, and therefore the VEGF-C/VEGF-D ratio was significantly increased in tumors compared with normal mucosae. However, neither mRNA expression of VEGF-C or VEGF-D nor the VEGF-C/VEGF-D ratio correlated with any clinicopathological factors, including lymphatic invasion, venous invasion, lymph node status, and tumor stage. VEGF-C and VEGF-D gene expression do not appear to be involved in the lymphatic progression of esophageal carcinoma. | |||||
書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 54, 号 3, p. 67-75, 発行日 2006-09 |
|||||
出版者 | ||||||
出版者 | Niigata University School of Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 05677734 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508361 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
値 | publisher |
Share
Cite as
Kaneko, Kouji, Koyama, Yu, Kanda, Tatsuo, Honma, Hideyuki, Ohashi, Manabu, Nakagawa, Satoru, Hatakeyama, Katsuyoshi, 2006, mRNA Expression of Vascular Endothelial Growth Factor-C and -D in Esophageal Squamous Cell Carcinoma: Niigata University School of Medicine, 67–75 p.
Loading...