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Peripheral CD5+B Cells Reflect Regional Immunity of the Liver in Pediatric Cholestatic Diseases
http://hdl.handle.net/10191/5237
http://hdl.handle.net/10191/52377fa45ce4-12fd-419b-ad10-a239eff25459
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
17_0010.pdf (634.0 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2008-04-08 | |||||
| タイトル | ||||||
| タイトル | Peripheral CD5+B Cells Reflect Regional Immunity of the Liver in Pediatric Cholestatic Diseases | |||||
| タイトル | ||||||
| タイトル | Peripheral CD5+B Cells Reflect Regional Immunity of the Liver in Pediatric Cholestatic Diseases | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cholestatic liver disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CD5+B cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | children | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunological abnormality | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lymphocyte subpopulation | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 著者 |
Iinuma, Yasushi
× Iinuma, Yasushi× Kubota, Masayuki× Yagi, Minoru× Kawamura, Hiroki× Tsuchida, Masahito× Takahashi, Satoshi× Abo, Toru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Certain immunological abnormalities are thought to be the causative factors in pediatric cholestatic diseases (PCD). However, few studies have been done regarding the simultaneous analysis of the lymphocyte phenotype of the liver and the peripheral blood (PBL) in PCD. To understand better the immunological background of PCD, we analyzed the lymphocyte subpopulations in the liver and in the PBL. Ten patients with PCD were investigated in this study: four patients with biliary atresia (BA), five patients with congenital biliary dilatation, and one patient with a paucity of interlobular bile ducts. Both liver tissue and peripheral blood samples were obtained during a total of ll incidences of surgery on these patients. The collected samples were analyzed with a FACScan. The expressions of CD4, CDS, CD20, CD56, CD5"CD20+ (CD5"B cells) and CD5+CD20+ (CD5+B cells) surface antigens were evaluated in the liver and PBL. The relative size of the lymphocyte subpopulations of CD4, CDS and CD56 in PBL respectively differed from those in the liver significantly. No significant correlation was observed between the relative amount in the PBL and that of the liver regarding each marker. The relative size of the CD5+B cells in the PBL was nearly same as that in the liver, and only CD5+B cells showed a significant positive correlation between these cells in the PBL and liver. The CD5+B cell subpopulation in the PBL may provide valuable, non-invasive information regarding the regional immunity of the liver in patients with PCD. | |||||
| 書誌情報 |
Acta medica et biologica en : Acta medica et biologica 巻 54, 号 4, p. 119-124, 発行日 2006-12 |
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| 出版者 | ||||||
| 出版者 | Niigata University School of Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 05677734 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508361 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
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Cite as
Iinuma, Yasushi, Kubota, Masayuki, Yagi, Minoru, Kawamura, Hiroki, Tsuchida, Masahito, Takahashi, Satoshi, Abo, Toru, 2006, Peripheral CD5+B Cells Reflect Regional Immunity of the Liver in Pediatric Cholestatic Diseases: Niigata University School of Medicine, 119–124 p.
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