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Effects of antimicrobial photodynamic therapy and local administration of minocycline on clinical, microbiological, and inflammatory markers of periodontal pockets
http://hdl.handle.net/10191/50273
http://hdl.handle.net/10191/5027303113233-4307-4199-88dc-60b4a0811e5d
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本文 (678.4 kB)
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要旨 (299.5 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2018-06-29 | |||||
| タイトル | ||||||
| タイトル | Effects of antimicrobial photodynamic therapy and local administration of minocycline on clinical, microbiological, and inflammatory markers of periodontal pockets | |||||
| タイトル | ||||||
| タイトル | Effects of antimicrobial photodynamic therapy and local administration of minocycline on clinical, microbiological, and inflammatory markers of periodontal pockets | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_46ec | |||||
| タイプ | thesis | |||||
| その他のタイトル | ||||||
| その他のタイトル | 歯周ポケットの臨床、微生物学的および炎症マーカーに及ぼす抗菌光線力学療法およびミノサイクリン局所投与の影響 | |||||
| 著者 |
Hokari, Takahiro
× Hokari, Takahiro |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 51312 | |||||
| 姓名 | 保苅, 崇大 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective. We evaluated the efficacies of antimicrobial photodynamic therapy (aPDT) and minocycline ointment (MO) on clinical and bacteriological markers and on the local host immune-inflammatory response. Materials and Methods. Thirty patients with chronic periodontitis were randomly assigned to two groups. Selected periodontal pockets (probing depth 5–7 mm with bleeding on probing) were treated with aPDT or MO as monotherapy. Measurement of clinical parameters and collection of gingival crevicular fluid (GCF) and subgingival plaque were performed at baseline, and at 1 and 4 weeks post-treatment. Quantification of periodontopathic bacteria in the sulcus and multiplex bead immunoassay of ten inflammatory cytokines in the GCF were performed. Results. Local MO administration resulted in substantial improvement in clinical parameters and a significant reduction in bacterial count (P < 0.01) and interleukin-1β and interferon-γ levels at 1 and 4 weeks after treatment (P < 0.01). There was no significant change in the aPDT group, except in clinical parameters. Conclusions. While local administration of MO exhibited beneficial effects on clinical and microbiological markers and crevicular cytokine levels in periodontal pockets, aPDT did not show any additional benefits within the limitations of this study. This trial is registered with UMIN Clinical Trials Registry UMIN000013376. | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 学位の種類: 博士（歯学）. 報告番号: 甲第4438号. 学位記番号: 新大院博（歯）甲第401号. 学位授与年月日: 平成30年3月23日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | International Journal of Dentistry. 2018 Apr, 2018, 1748584. | |||||
| 書誌情報 | p. 1-38, 発行日 2018-03-23 | |||||
| 出版者 | ||||||
| 出版者 | 新潟大学 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1155/2018/1748584 | |||||
| 著者版フラグ | ||||||
| 値 | ETD | |||||
| 学位名 | ||||||
| 学位名 | 博士（歯学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関名 | 新潟大学 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2018-03-23 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 13101甲第4438号 | |||||
| 学位記番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新大院博（歯）甲第401号 | |||||
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Cite as
Hokari, Takahiro, 2018, Effects of antimicrobial photodynamic therapy and local administration of minocycline on clinical, microbiological, and inflammatory markers of periodontal pockets: 新潟大学, p. 1–38.
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