@misc{oai:niigata-u.repo.nii.ac.jp:00006055,
 author = {Hokari, Takahiro},
 month = {Mar},
 note = {Objective. We evaluated the efficacies of antimicrobial photodynamic therapy (aPDT) and minocycline ointment (MO) on clinical and bacteriological markers and on the local host immune-inflammatory response. Materials and Methods. Thirty patients with chronic periodontitis were randomly assigned to two groups. Selected periodontal pockets (probing depth 5–7 mm with bleeding on probing) were treated with aPDT or MO as monotherapy. Measurement of clinical parameters and collection of gingival crevicular fluid (GCF) and subgingival plaque were performed at baseline, and at 1 and 4 weeks post-treatment. Quantification of periodontopathic bacteria in the sulcus and multiplex bead immunoassay of ten inflammatory cytokines in the GCF were performed. Results. Local MO administration resulted in substantial improvement in clinical parameters and a significant reduction in bacterial count (P < 0.01) and interleukin-1β and interferon-γ levels at 1 and 4 weeks after treatment (P < 0.01). There was no significant change in the aPDT group, except in clinical parameters. Conclusions. While local administration of MO exhibited beneficial effects on clinical and microbiological markers and crevicular cytokine levels in periodontal pockets, aPDT did not show any additional benefits within the limitations of this study. This trial is registered with UMIN Clinical Trials Registry UMIN000013376., 学位の種類: 博士（歯学）. 報告番号: 甲第4438号. 学位記番号: 新大院博（歯）甲第401号. 学位授与年月日: 平成30年3月23日, International Journal of Dentistry. 2018 Apr, 2018, 1748584., 新大院博（歯）甲第401号},
 title = {Effects of antimicrobial photodynamic therapy and local administration of minocycline on clinical, microbiological, and inflammatory markers of periodontal pockets},
 year = {2018}
}