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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies

http://hdl.handle.net/10191/50416
http://hdl.handle.net/10191/50416
63b4a07f-8ee1-4ed2-bb53-36287ff7f0b0
名前 / ファイル ライセンス アクション
h29nmk802.pdf 本文 (59.6 MB)
h29nmk802_a.pdf 要旨 (734.2 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2018-07-26
タイトル
タイトル Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies
タイトル
言語 en
タイトル Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
その他のタイトル
その他のタイトル 内部欠失による変異BCORによりT細胞腫瘍におけるBCORのがん抑制遺伝子としての機能が明らかとなった
著者 Tanaka, Tomoyuki

× Tanaka, Tomoyuki

WEKO 51228

Tanaka, Tomoyuki

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著者別名
識別子 51229
識別子Scheme WEKO
姓名 田中, 智之
抄録
内容記述タイプ Abstract
内容記述 Recurrent inactivating mutations have been identified in various hematological malignancies in the X-linked BCOR gene encoding BCL6 corepressor (BCOR). However, its tumor suppressor function remains largely uncharacterized. We herein generated mice missing Bcor exon 4, expressing a variant BCOR lacking the BCL6-binding domain. While the deletion of exon 4 in male mice (Bcor^ <ΔE4/y>) compromised the repopulating capacity of hematopoietic stem cells, Bcor^<ΔE4/y> thymocytes had augmented proliferative capacity in culture and showed a strong propensity to induce acute T-cell lymphoblastic leukemia (T-ALL) mostly in a Notch-dependent manner. Myc, one of the critical NOTCH1 targets in T-ALL, was highly upregulated in Bcor^<ΔE4/y> T-ALL cells. ChIP-seq analysis revealed that BCOR was recruited to the Myc promoter and restrained its activation in thymocytes. BCOR also targeted other NOTCH1 targets and potentially antagonized their transcriptional activation. Bcl6-deficient thymocytes behaved in a similar manner to Bcor^<ΔE4/y> thymocytes. Our results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies.
内容記述
内容記述タイプ Other
内容記述 学位の種類: 博士(医学). 報告番号: 甲第4403号. 学位記番号: 新大院博(医)甲第802号. 学位授与年月日: 平成30年3月23日
内容記述
内容記述タイプ Other
内容記述 Journal of Experimental Medicine. 2017. 214(10), 2901-2913.
書誌情報 p. 1-37, 発行日 2018-03-23
出版者
出版者 新潟大学
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1084/jem.20170167
著者版フラグ
値 ETD
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名 新潟大学
学位授与年月日
学位授与年月日 2018-03-23
学位授与番号
学位授与番号 13101甲第4403号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)甲第802号
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