{"_buckets": {"deposit": "345f9f05-d8df-403f-91ee-3dd2a4c16255"}, "_deposit": {"id": "6001", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "6001"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00006001", "sets": ["455", "562"]}, "item_6_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "内部欠失による変異BCORによりT細胞腫瘍におけるBCORのがん抑制遺伝子としての機能が明らかとなった"}]}, "item_6_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-03-23", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "37", "bibliographicPageStart": "1", "bibliographic_titles": [{}]}]}, "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2018-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "新潟大学"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Recurrent inactivating mutations have been identified in various hematological malignancies in the X-linked BCOR gene encoding BCL6 corepressor (BCOR). However, its tumor suppressor function remains largely uncharacterized. We herein generated mice missing Bcor exon 4, expressing a variant BCOR lacking the BCL6-binding domain. While the deletion of exon 4 in male mice (Bcor^ \u003cΔE4/y\u003e) compromised the repopulating capacity of hematopoietic stem cells, Bcor^\u003cΔE4/y\u003e thymocytes had augmented proliferative capacity in culture and showed a strong propensity to induce acute T-cell lymphoblastic leukemia (T-ALL) mostly in a Notch-dependent manner. Myc, one of the critical NOTCH1 targets in T-ALL, was highly upregulated in Bcor^\u003cΔE4/y\u003e T-ALL cells. ChIP-seq analysis revealed that BCOR was recruited to the Myc promoter and restrained its activation in thymocytes. BCOR also targeted other NOTCH1 targets and potentially antagonized their transcriptional activation. Bcl6-deficient thymocytes behaved in a similar manner to Bcor^\u003cΔE4/y\u003e thymocytes. Our results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies.", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "学位の種類: 博士（医学）. 報告番号: 甲第4403号. 学位記番号: 新大院博（医）甲第802号. 学位授与年月日: 平成30年3月23日", "subitem_description_type": "Other"}, {"subitem_description": "Journal of Experimental Medicine. 2017.  214(10), 2901-2913.", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博（医）甲第802号", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "13101甲第4403号"}]}, "item_6_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "51229", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "田中, 智之"}]}]}, "item_6_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟大学"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1084/jem.20170167", "subitem_relation_type_select": "DOI"}}]}, "item_6_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "ETD"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tanaka, Tomoyuki"}], "nameIdentifiers": [{"nameIdentifier": "51228", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "h29nmk802.pdf", "filesize": [{"value": "59.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 59600000.0, "url": {"label": "本文", "url": "https://niigata-u.repo.nii.ac.jp/record/6001/files/h29nmk802.pdf"}, "version_id": "4181e4c0-dbe2-4014-9e25-46abd1340820"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "h29nmk802_a.pdf", "filesize": [{"value": "734.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 734200.0, "url": {"label": "要旨", "url": "https://niigata-u.repo.nii.ac.jp/record/6001/files/h29nmk802_a.pdf"}, "version_id": "2fec0b1b-20bc-465b-adaf-5b1e6c893ad9"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies"}, {"subitem_title": "Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies", "subitem_title_language": "en"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/50416", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-07-26"}, "publish_date": "2018-07-26", "publish_status": "0", "recid": "6001", "relation": {}, "relation_version_is_last": true, "title": ["Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies"], "weko_shared_id": 2}