{"created":"2021-03-01T06:09:53.148766+00:00","id":6001,"links":{},"metadata":{"_buckets":{"deposit":"345f9f05-d8df-403f-91ee-3dd2a4c16255"},"_deposit":{"id":"6001","owners":[],"pid":{"revision_id":0,"type":"depid","value":"6001"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00006001","sets":["453:455","471:561:562"]},"item_6_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"内部欠失による変異BCORによりT細胞腫瘍におけるBCORのがん抑制遺伝子としての機能が明らかとなった"}]},"item_6_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03-23","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"37","bibliographicPageStart":"1","bibliographic_titles":[{}]}]},"item_6_date_granted_51":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-23"}]},"item_6_degree_grantor_49":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"新潟大学"}]}]},"item_6_degree_name_48":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_6_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recurrent inactivating mutations have been identified in various hematological malignancies in the X-linked BCOR gene encoding BCL6 corepressor (BCOR). However, its tumor suppressor function remains largely uncharacterized. We herein generated mice missing Bcor exon 4, expressing a variant BCOR lacking the BCL6-binding domain. While the deletion of exon 4 in male mice (Bcor^ <ΔE4/y>) compromised the repopulating capacity of hematopoietic stem cells, Bcor^<ΔE4/y> thymocytes had augmented proliferative capacity in culture and showed a strong propensity to induce acute T-cell lymphoblastic leukemia (T-ALL) mostly in a Notch-dependent manner. Myc, one of the critical NOTCH1 targets in T-ALL, was highly upregulated in Bcor^<ΔE4/y> T-ALL cells. ChIP-seq analysis revealed that BCOR was recruited to the Myc promoter and restrained its activation in thymocytes. BCOR also targeted other NOTCH1 targets and potentially antagonized their transcriptional activation. Bcl6-deficient thymocytes behaved in a similar manner to Bcor^<ΔE4/y> thymocytes. Our results provide the first evidence of a tumor suppressor role for BCOR in the pathogenesis of T lymphocyte malignancies.","subitem_description_type":"Abstract"}]},"item_6_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"学位の種類: 博士（医学）. 報告番号: 甲第4403号. 学位記番号: 新大院博（医）甲第802号. 学位授与年月日: 平成30年3月23日","subitem_description_type":"Other"},{"subitem_description":"Journal of Experimental Medicine. 2017.  214(10), 2901-2913.","subitem_description_type":"Other"}]},"item_6_description_53":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_description":"新大院博（医）甲第802号","subitem_description_type":"Other"}]},"item_6_dissertation_number_52":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"13101甲第4403号"}]},"item_6_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"51229","nameIdentifierScheme":"WEKO"}],"names":[{"name":"田中, 智之"}]}]},"item_6_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟大学"}]},"item_6_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1084/jem.20170167","subitem_relation_type_select":"DOI"}}]},"item_6_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"ETD"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanaka, Tomoyuki"}],"nameIdentifiers":[{"nameIdentifier":"51228","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h29nmk802.pdf","filesize":[{"value":"59.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://niigata-u.repo.nii.ac.jp/record/6001/files/h29nmk802.pdf"},"version_id":"4181e4c0-dbe2-4014-9e25-46abd1340820"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-05"}],"displaytype":"detail","filename":"h29nmk802_a.pdf","filesize":[{"value":"734.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"要旨","url":"https://niigata-u.repo.nii.ac.jp/record/6001/files/h29nmk802_a.pdf"},"version_id":"2fec0b1b-20bc-465b-adaf-5b1e6c893ad9"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies"},{"subitem_title":"Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies","subitem_title_language":"en"}]},"item_type_id":"6","owner":"1","path":["455","562"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-07-26"},"publish_date":"2018-07-26","publish_status":"0","recid":"6001","relation_version_is_last":true,"title":["Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies"],"weko_creator_id":"1","weko_shared_id":2},"updated":"2022-12-15T03:39:20.602449+00:00"}